ITGA1 and AUP1

Number of citations: 0 (PubMedID 12042322)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ITGA1	AUP1
Name		integrin subunit alpha 1	AUP1 lipid droplet regulating VLDL assembly factor
Structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Perikaryon Basal Part Of Cell Extracellular Exosome	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Collagen Binding Phosphatase Activator Activity Protein Phosphatase Binding Signaling Receptor Activity Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis Cell Chemotaxis Cell-cell Adhesion	Response To Virus Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization ERAD Pathway Lipophagy Lipid Droplet Formation Protein Localization To Lipid Droplet
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	None
GWAS		Acne (severe) ( 24927181 ) Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease biomarkers ( 23419831 ) Apolipoprotein B levels ( 32203549 ) Attention deficit hyperactivity disorder ( 28809852 ) Chronic obstructive pulmonary disease ( 30804561 ) Coronary artery disease ( 26708285 ) FEV1 ( 30804560 ) Gamma glutamyl transferase levels ( 33339817 29403010 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 26708285 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pulse pressure ( 30578418 30224653 ) Red blood cell count ( 32888494 ) Response to platinum-based agents ( 22020760 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Serum total protein levels ( 29403010 ) Total cholesterol levels ( 30275531 ) Type 2 diabetes ( 30297969 29926116 30718926 32499647 30130595 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1	10 interacting genes: GRSF1 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2
Entrez ID		3672	550
HPRD ID		01892	03892
Ensembl ID		ENSG00000213949	ENSG00000115307
Uniprot IDs		P56199	Q9Y679
PDB IDs		1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ	2EKF 7LEW
GO Terms Enriched among Interactors		Cell Differentiation Extracellular Matrix Basement Membrane Cell Adhesion Integrin Binding Lipid Tube Assembly Regulation Of Multicellular Organismal Development Cellular Developmental Process Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cell Adhesion Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Collagen Type VIII Trimer Anatomical Structure Morphogenesis Collagen Type XIII Trimer Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Protease Binding Developmental Process Ubiquitin Binding Lipophagy Cell-matrix Adhesion Ruffle Integrin-mediated Signaling Pathway Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Ruffle Membrane Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Laminin-1 Complex Laminin-3 Complex	Integrin Complex Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-substrate Adhesion Signaling Receptor Activity External Side Of Plasma Membrane Cell-cell Adhesion Cell Surface Cell Adhesion Mediated By Integrin Integrin Binding Heterotypic Cell-cell Adhesion Focal Adhesion Cell Adhesion Collagen Binding Involved In Cell-matrix Adhesion Virus Receptor Activity Wound Healing, Spreading Of Epidermal Cells Basal Part Of Cell Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Response To Muscle Activity Extracellular Matrix Binding Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Formation Of Primary Germ Layer Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Angiogenesis Collagen Binding Integrin Alpha1-beta1 Complex Cell Migration Metal Ion Binding Amyloid-beta Binding Female Pregnancy Response To Activity Integrin Alpha5-beta1 Complex Integrin AlphaM-beta2 Complex Specific Granule Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex