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ITGA1 and PTPN2
Number of citations of the paper that reports this interaction (PMID
15592458
)
42
Data Source:
HPRD
(in vitro, two hybrid)
ITGA1
PTPN2
Gene Name
integrin, alpha 1
protein tyrosine phosphatase, non-receptor type 2
Image
Gene Ontology Annotations
Cellular Component
Acrosomal Vesicle
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin Alpha1-beta1 Complex
Neuron Projection
Perikaryon
Membrane Raft
Basal Part Of Cell
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Molecular Function
Receptor Binding
Protein Binding
Collagen Binding
Protein Phosphatase Binding
Metal Ion Binding
Collagen Binding Involved In Cell-matrix Adhesion
Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
Protein Kinase Binding
Syntaxin Binding
Receptor Tyrosine Kinase Binding
Biological Process
Activation Of MAPK Activity
Muscle Contraction
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Axon Guidance
Blood Coagulation
Negative Regulation Of Cell Proliferation
Extracellular Matrix Organization
Neutrophil Chemotaxis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vasodilation
Positive Regulation Of Neuron Apoptotic Process
Cellular Extravasation
Negative Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
Cytokine-mediated Signaling Pathway
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein
Glucose Homeostasis
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Prolactin Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways
Platelet Adhesion to exposed collagen
CHL1 interactions
Axon guidance
Laminin interactions
Semaphorin interactions
Other semaphorin interactions
Smooth Muscle Contraction
L1CAM interactions
Integrin cell surface interactions
Drugs
Diseases
GWAS
Alzheimer's disease biomarkers (
23419831
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Pulmonary function (
21946350
)
Pulmonary function (interaction) (
23284291
)
Response to platinum-based agents (
22020760
)
C-reactive protein (
21300955
)
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
21383967
)
Crohn's disease (
18587394
17554261
17554300
21102463
)
Esophageal cancer (squamous cell) (
22960999
)
Rheumatoid arthritis (
22446963
)
Type 1 diabetes (
19430480
17554260
18978792
)
Type 1 diabetes autoantibodies (
21829393
)
Protein-Protein Interactions
10 interactors:
AUP1
BIN1
COL13A1
COL8A1
ITGB1
LAMA1
MATN1
PTPN2
SHARPIN
TLN1
18 interactors:
CDK1
CDK2
CDK5
EGFR
FKBP4
GHR
INSR
ITGA1
JAK1
JAK3
KPNB1
PDGFRB
SHC1
SRC
STAT1
STAT3
STAT5A
STAT5B
Entrez ID
3672
5771
HPRD ID
01892
06768
Ensembl ID
ENSG00000175354
Uniprot IDs
P56199
A8K3N4
K7ENG3
K7EQG9
P17706
Q59F91
PDB IDs
1PT6
1QC5
1QCY
2L8S
4A0Q
1L8K
Enriched GO Terms of Interacting Partners
?
Cell Differentiation
Extracellular Matrix Organization
Extracellular Structure Organization
System Development
Multicellular Organismal Development
Anatomical Structure Development
Cell Adhesion
Developmental Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Organ Development
Single Organismal Cell-cell Adhesion
Regulation Of Cell Adhesion
Anatomical Structure Morphogenesis
Cell Morphogenesis Involved In Differentiation
Tissue Development
Collagen Catabolic Process
Cellular Component Assembly
Organ Morphogenesis
Axon Guidance
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Prolactin Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Growth Plate Cartilage Chondrocyte Morphogenesis
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Collagen Metabolic Process
Cell Morphogenesis
Blood Vessel Morphogenesis
Endochondral Bone Morphogenesis
Multicellular Organismal Macromolecule Metabolic Process
Multicellular Organismal Metabolic Process
Extracellular Matrix Disassembly
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Endocytosis
B Cell Differentiation
Negative Regulation Of Inflammatory Response
Blood Vessel Development
Nervous System Development
Lipid Tube Assembly
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Positive Regulation Of Cell-substrate Adhesion
Cell-cell Junction Assembly
Axonogenesis
Vasculature Development
Bone Morphogenesis
Axon Development
Formation Of Primary Germ Layer
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Cellular Response To Organonitrogen Compound
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Growth Hormone Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Regulation Of Cell Proliferation
Response To Organonitrogen Compound
Cellular Response To Hormone Stimulus
Peptidyl-tyrosine Phosphorylation
Response To Peptide Hormone
Response To Hormone
Response To Growth Hormone
Peptidyl-amino Acid Modification
Response To Peptide
Intracellular Signal Transduction
Cellular Response To Organic Substance
JAK-STAT Cascade
Positive Regulation Of MAP Kinase Activity
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Signaling
Positive Regulation Of DNA Metabolic Process
Cell Communication
Protein Phosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase Activity
Regulation Of MAP Kinase Activity
Phosphorylation
Positive Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Proliferation
Positive Regulation Of Transferase Activity
Positive Regulation Of Cellular Biosynthetic Process
Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Immune Response
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of MAPK Cascade
Cytokine-mediated Signaling Pathway
Response To Cytokine
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Tagcloud
?
6alpha
acidic
astrocytes
astroglial
atf6alpha
ciliary
cntf
deactivation
dissect
fibrillary
gfap
glia
glial
infarct
lif
master
mcao
neurotrophic
peri
phenylbutyrate
protein78
scar
stressors
tc
thapsigargin
transducer
tunicamycin
unfolded
Tagcloud (Difference)
?
6alpha
acidic
astrocytes
astroglial
atf6alpha
ciliary
cntf
deactivation
dissect
fibrillary
gfap
glia
glial
infarct
lif
master
mcao
neurotrophic
peri
phenylbutyrate
protein78
scar
stressors
tc
thapsigargin
transducer
tunicamycin
unfolded
Tagcloud (Intersection)
?