ITGA1

Name	integrin subunit alpha 1
Structure
Interactors	10 interactors: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Perikaryon Basal Part Of Cell Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Collagen Binding Phosphatase Activator Activity Protein Phosphatase Binding Signaling Receptor Activity Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis Cell Chemotaxis Cell-cell Adhesion
Pathways	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen
GWAS	Acne (severe) ( 24927181 ) Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease biomarkers ( 23419831 ) Apolipoprotein B levels ( 32203549 ) Attention deficit hyperactivity disorder ( 28809852 ) Chronic obstructive pulmonary disease ( 30804561 ) Coronary artery disease ( 26708285 ) FEV1 ( 30804560 ) Gamma glutamyl transferase levels ( 33339817 29403010 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 26708285 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pulse pressure ( 30578418 30224653 ) Red blood cell count ( 32888494 ) Response to platinum-based agents ( 22020760 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Serum total protein levels ( 29403010 ) Total cholesterol levels ( 30275531 ) Type 2 diabetes ( 30297969 29926116 30718926 32499647 30130595 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )
Entrez ID	3672
HPRD ID	01892
Ensembl ID	ENSG00000213949
Uniprot IDs	P56199
PDB IDs	1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ
GO Terms Enriched among Interactors ?	Cell Differentiation Extracellular Matrix Basement Membrane Cell Adhesion Integrin Binding Lipid Tube Assembly Regulation Of Multicellular Organismal Development Cellular Developmental Process Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cell Adhesion Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Collagen Type VIII Trimer Anatomical Structure Morphogenesis Collagen Type XIII Trimer Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Protease Binding Developmental Process Ubiquitin Binding Lipophagy Cell-matrix Adhesion Ruffle Integrin-mediated Signaling Pathway Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Ruffle Membrane Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Laminin-1 Complex Laminin-3 Complex