IL13 and S100P

Number of citations of the paper that reports this interaction (PubMedID 36233301)
61

Data Source:
BioGRID (pull down)

		IL13	S100P
Description		interleukin 13	S100 calcium binding protein P
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-13 Receptor Binding Protein Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Response To Mechanical Stimulus Response To Nematode Regulation Of Proton Transport Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Transforming Growth Factor Beta1 Production Response To Nicotine Interleukin-13-mediated Signaling Pathway Macrophage Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Endothelial Cell Migration
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Neutrophil degranulation
Drugs		Cintredekin besudotox Lebrikizumab Lebrikizumab Dupilumab Tralokinumab Romilkimab	Cromoglicic acid
Diseases		Graft-versus-host disease Asthma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 20860503 34103634 32296059 31959851 31619474 31361310 29785011 29273806) Asthma (childhood onset) ( 24241537 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879 25574825 23727859 23886662) Childhood asthma with severe exacerbations ( 33328473) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 22286212 24920014) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Lymphocyte count ( 32888494) Psoriasis ( 25574825 19169254 23143594 25903422) Psoriasis vulgaris ( 26626624) Rosacea symptom severity ( 29771307)	Obesity-related traits ( 23251661)
Interacting Genes		8 interacting genes: CFTR IL13RA1 IL13RA2 IL4R PIK3R1 S100A6 S100P VCAM1	46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A
Entrez ID		3596	6286
HPRD ID		00981	02792
Ensembl ID		ENSG00000169194	ENSG00000163993
Uniprot IDs		P35225 Q4VB53	P25815
PDB IDs		1GA3 1IJZ 1IK0 3BPO 3G6D 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y 8BLQ	1J55 1OZO 2MJW 7NMI
Enriched GO Terms of Interacting Partners?		Cytokine Receptor Activity Regulation Of Immunoglobulin Production External Side Of Plasma Membrane Plasma Membrane Cytokine-mediated Signaling Pathway Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Regulation Of Exocytosis Regulation Of Production Of Molecular Mediator Of Immune Response Receptor Complex Regulation Of Mast Cell Degranulation T-helper Cell Differentiation Immunoglobulin Mediated Immune Response Lymphocyte Differentiation Cytokine Binding T Cell Differentiation Involved In Immune Response B Cell Mediated Immunity CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Immune System Process CD4-positive, Alpha-beta T Cell Activation Mononuclear Cell Differentiation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Alpha-beta T Cell Differentiation Interleukin-13 Receptor Complex Positive Regulation Of Cell Population Proliferation Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation T Cell Activation Involved In Immune Response Leukocyte Differentiation Calcium-dependent Protein Binding Immune Effector Process Membrane Positive Regulation Of Exocytosis Membrane Docking Positive Regulation Of Immune System Process Positive Regulation Of Anion Channel Activity Alpha-beta T Cell Activation Interleukin-4 Receptor Activity Peripheral Nervous System Neuron Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Activation Extracellular Region B Cell Differentiation Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Hemopoiesis Lymphocyte Activation Involved In Immune Response Interleukin-13-mediated Signaling Pathway	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation
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