IL13 and IL13RA1

Number of citations of the paper that reports this interaction (PMID 11278629)
1

Data Source:
HPRD (in vivo)

		IL13	IL13RA1
Gene Name		interleukin 13	interleukin 13 receptor, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Plasma Membrane Interleukin-13 Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding	Protein Binding Interleukin-13 Receptor Activity
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Regulation Of Proton Transport Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Positive Regulation Of Macrophage Activation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Interleukin-13-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Asthma ( 20860503) Atopic dermatitis ( 23042114) Hodgkin's lymphoma ( 22286212) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Psoriasis ( 19169254)
Protein-Protein Interactions		6 interactors: IL13RA1 IL13RA2 IL4 IL4R PIK3R1 VCAM1	6 interactors: DLG4 IL13 IL4R TMEM39B TRAF3IP1 TYK2
Entrez ID		3596	3597
HPRD ID		00981	02125
Ensembl ID		ENSG00000169194	ENSG00000131724
Uniprot IDs		P35225	P78552
PDB IDs		1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3L5Y 3LB6 4I77	3BPN 3BPO 4HWB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Cytokine Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion B Cell Differentiation Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of T-helper Cell Differentiation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Immune System Process Negative Regulation Of Alpha-beta T Cell Differentiation Cellular Response To Cytokine Stimulus B Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Defense Response To Protozoan Negative Regulation Of Cell Adhesion Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Macrophage Activation Response To Protozoan Cellular Response To Organic Substance Lymphocyte Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Immune Response Regulation Of T-helper Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Adaptive Immune Response Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Leukocyte Differentiation Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cytokine Production Negative Regulation Of Immune System Process Regulation Of Chemokine Production Regulation Of B Cell Proliferation Lymphocyte Activation Regulation Of Osteoclast Differentiation Immune Response Signal Transduction	Positive Regulation Of Macrophage Activation Regulation Of Macrophage Activation Regulation Of Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Response To Cytokine Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Protein Secretion Negative Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Production Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Regulation Of Signaling Maintenance Of Apical/basal Cell Polarity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Immune Response Positive Regulation Of Cell Activation Receptor Localization To Synapse Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Defense Response Positive Regulation Of Chemokine Secretion Negative Regulation Of Receptor Internalization Positive Regulation Of Secretion Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Protein Transport Negative Regulation Of T-helper Cell Differentiation Locomotory Exploration Behavior Regulation Of Cell Proliferation Positive Regulation Of Cytokine Production Dendritic Spine Morphogenesis Negative Regulation Of Immune System Process Synaptic Vesicle Maturation Interleukin-4-mediated Signaling Pathway Maintenance Of Cell Polarity Regulation Of Lymphocyte Activation Regulation Of Proton Transport Regulation Of Protein Secretion Negative Regulation Of Alpha-beta T Cell Differentiation Microglial Cell Activation
Tagcloud ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	1b aiming balance bearing ccl24 clec4a2 decline delta depends elucidating eotaxin fold gm h37rv hour il12b immunological inb1 initiated mce1 microarrays plex post ppargamma pro qpcr switch tuberculosis uninfected
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	1b aiming balance bearing ccl24 clec4a2 decline delta depends elucidating eotaxin fold gm h37rv hour il12b immunological inb1 initiated mce1 microarrays plex post ppargamma pro qpcr switch tuberculosis uninfected
Tagcloud (Intersection) ?