IL13 and VCAM1

Number of citations of the paper that reports this interaction (PubMedID 7521694)
0

Data Source:
HPRD (in vitro)

		IL13	VCAM1
Description		interleukin 13	vascular cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Podosome Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-13 Receptor Binding Protein Binding	Integrin Binding Primary Methylamine Oxidase Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Response To Mechanical Stimulus Response To Nematode Regulation Of Proton Transport Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Transforming Growth Factor Beta1 Production Response To Nicotine Interleukin-13-mediated Signaling Pathway Macrophage Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Response To Hypoxia Chronic Inflammatory Response Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Membrane To Membrane Docking B Cell Differentiation Response To Lipopolysaccharide Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Leukocyte Tethering Or Rolling Cell Chemotaxis Innervation Cardiac Neuron Differentiation Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Cellular Response To Amyloid-beta
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		Cintredekin besudotox Lebrikizumab Lebrikizumab Dupilumab Tralokinumab Romilkimab	Ethanol Carvedilol Succinobucol Clove oil
Diseases		Graft-versus-host disease Asthma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 20860503 34103634 32296059 31959851 31619474 31361310 29785011 29273806) Asthma (childhood onset) ( 24241537 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879 25574825 23727859 23886662) Childhood asthma with severe exacerbations ( 33328473) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 22286212 24920014) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Lymphocyte count ( 32888494) Psoriasis ( 25574825 19169254 23143594 25903422) Psoriasis vulgaris ( 26626624) Rosacea symptom severity ( 29771307)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088 24076602 31604244) Neutrophil percentage of white cells ( 32888494) Sjögren's syndrome ( 24097067)
Interacting Genes		8 interacting genes: CFTR IL13RA1 IL13RA2 IL4R PIK3R1 S100A6 S100P VCAM1	13 interacting genes: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN TRIM54 TRIM65 USP2
Entrez ID		3596	7412
HPRD ID		00981	01888
Ensembl ID		ENSG00000169194	ENSG00000162692
Uniprot IDs		P35225 Q4VB53	P19320
PDB IDs		1GA3 1IJZ 1IK0 3BPO 3G6D 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y 8BLQ	1IJ9 1VCA 1VSC
Enriched GO Terms of Interacting Partners?		Cytokine Receptor Activity Regulation Of Immunoglobulin Production External Side Of Plasma Membrane Plasma Membrane Cytokine-mediated Signaling Pathway Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Regulation Of Exocytosis Regulation Of Production Of Molecular Mediator Of Immune Response Receptor Complex Regulation Of Mast Cell Degranulation T-helper Cell Differentiation Immunoglobulin Mediated Immune Response Lymphocyte Differentiation Cytokine Binding T Cell Differentiation Involved In Immune Response B Cell Mediated Immunity CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Immune System Process CD4-positive, Alpha-beta T Cell Activation Mononuclear Cell Differentiation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Alpha-beta T Cell Differentiation Interleukin-13 Receptor Complex Positive Regulation Of Cell Population Proliferation Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation T Cell Activation Involved In Immune Response Leukocyte Differentiation Calcium-dependent Protein Binding Immune Effector Process Membrane Positive Regulation Of Exocytosis Membrane Docking Positive Regulation Of Immune System Process Positive Regulation Of Anion Channel Activity Alpha-beta T Cell Activation Interleukin-4 Receptor Activity Peripheral Nervous System Neuron Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Activation Extracellular Region B Cell Differentiation Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Hemopoiesis Lymphocyte Activation Involved In Immune Response Interleukin-13-mediated Signaling Pathway	Immune System Process Immune Response Leukocyte Cell-cell Adhesion Leukocyte Migration Cell Adhesion Molecule Binding Integrin Complex Killing Of Cells Of Another Organism Inflammatory Response Heterotypic Cell-cell Adhesion Cell Migration Defense Response Membrane To Membrane Docking Cell Motility Response To Other Organism Cell Killing Defense Response To Symbiont Positive Regulation Of Early Endosome To Late Endosome Transport Defense Response To Other Organism Positive Regulation Of Protein Localization To Early Endosome Neutrophil-mediated Killing Of Bacterium Filopodium Cell-cell Adhesion Positive Regulation Of Protein Localization To Endosome Response To External Biotic Stimulus Uropod Integrin-mediated Signaling Pathway Cell-matrix Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Mononuclear Cell Migration Regulation Of Early Endosome To Late Endosome Transport Extracellular Space Leukocyte Tethering Or Rolling Neutrophil Mediated Immunity Cell Surface Establishment Of Apical/basal Cell Polarity Leukocyte Adhesion To Vascular Endothelial Cell Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Adhesion Mediated By Integrin Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell-substrate Adhesion Antimicrobial Humoral Response Killing By Host Of Symbiont Cells Cytokine-mediated Signaling Pathway Focal Adhesion T Cell Migration Biological Process Involved In Interaction With Symbiont
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