IL13 and IL13RA2

Number of citations: 0 (PubMedID 11003391)
Data Source: HPRD (in vitro, in vivo)

		IL13	IL13RA2
Name		interleukin 13	interleukin 13 receptor subunit alpha 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-13 Receptor Binding Protein Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Response To Mechanical Stimulus Response To Nematode Regulation Of Proton Transport Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Transforming Growth Factor Beta1 Production Response To Nicotine Interleukin-13-mediated Signaling Pathway Macrophage Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta1 Production Interleukin-13-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		Cintredekin besudotox Lebrikizumab Lebrikizumab Dupilumab Tralokinumab Romilkimab	AER001
Diseases		Graft-versus-host disease Asthma	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 30013184 ) Allergy ( 27182965 ) Alopecia areata ( 25608926 ) Asthma ( 20860503 34103634 32296059 31959851 31619474 31361310 29785011 29273806 ) Asthma (childhood onset) ( 24241537 29273806 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 23042114 26482879 25574825 23727859 23886662 ) Childhood asthma with severe exacerbations ( 33328473 ) Cutaneous psoriasis ( 26626624 ) Hodgkin's lymphoma ( 22286212 24920014 ) IgE levels ( 22075330 ) Inflammatory bowel disease ( 23128233 ) Lymphocyte count ( 32888494 ) Psoriasis ( 25574825 19169254 23143594 25903422 ) Psoriasis vulgaris ( 26626624 ) Rosacea symptom severity ( 29771307 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: CFTR IL13RA1 IL13RA2 IL4R PIK3R1 S100A6 S100P VCAM1	17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1
Entrez ID		3596	3598
HPRD ID		00981	02132
Ensembl ID		ENSG00000169194	ENSG00000123496
Uniprot IDs		P35225 Q4VB53	Q14627
PDB IDs		1GA3 1IJZ 1IK0 3BPO 3G6D 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y 8BLQ	3LB6
GO Terms Enriched among Interactors		Cytokine Receptor Activity Regulation Of Immunoglobulin Production External Side Of Plasma Membrane Plasma Membrane Cytokine-mediated Signaling Pathway Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Regulation Of Exocytosis Regulation Of Production Of Molecular Mediator Of Immune Response Receptor Complex Regulation Of Mast Cell Degranulation T-helper Cell Differentiation Immunoglobulin Mediated Immune Response Lymphocyte Differentiation Cytokine Binding T Cell Differentiation Involved In Immune Response B Cell Mediated Immunity CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Immune System Process CD4-positive, Alpha-beta T Cell Activation Mononuclear Cell Differentiation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Alpha-beta T Cell Differentiation Interleukin-13 Receptor Complex Positive Regulation Of Cell Population Proliferation Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation T Cell Activation Involved In Immune Response Leukocyte Differentiation Calcium-dependent Protein Binding Immune Effector Process Membrane Positive Regulation Of Exocytosis Membrane Docking Positive Regulation Of Immune System Process Positive Regulation Of Anion Channel Activity Alpha-beta T Cell Activation Interleukin-4 Receptor Activity Peripheral Nervous System Neuron Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Activation Extracellular Region B Cell Differentiation Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Hemopoiesis Lymphocyte Activation Involved In Immune Response Interleukin-13-mediated Signaling Pathway	Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Multicellular Organismal Process Immune System Process Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process ERBB Signaling Pathway Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Animal Organ Development Positive Regulation Of Immune System Process Regulation Of Developmental Process Positive Regulation Of Cold-induced Thermogenesis Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Immune System Process Response To Lipid Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Leukocyte Activation Apoptotic Process Regulation Of Cold-induced Thermogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Locomotion Cell Death Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Developmental Process Defense Response Interleukin-4-mediated Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Activation