IL13 and IL13RA2

Number of citations of the paper that reports this interaction (PMID 11003391)
0

Data Source:
HPRD (in vivo, in vitro)

		IL13	IL13RA2
Gene Name		interleukin 13	interleukin 13 receptor, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Extracellular Space Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding	Signal Transducer Activity Cytokine Receptor Activity
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Regulation Of Proton Transport Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Positive Regulation Of Macrophage Activation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Signal Transduction Cytokine-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Asthma ( 20860503) Atopic dermatitis ( 23042114) Hodgkin's lymphoma ( 22286212) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Psoriasis ( 19169254)
Protein-Protein Interactions		6 interactors: IL13RA1 IL13RA2 IL4 IL4R PIK3R1 VCAM1	2 interactors: IL13 IL4
Entrez ID		3596	3598
HPRD ID		00981	02132
Ensembl ID		ENSG00000169194	ENSG00000123496
Uniprot IDs		P35225	Q14627
PDB IDs		1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3L5Y 3LB6 4I77	3LB6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Cytokine Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion B Cell Differentiation Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of T-helper Cell Differentiation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Immune System Process Negative Regulation Of Alpha-beta T Cell Differentiation Cellular Response To Cytokine Stimulus B Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Defense Response To Protozoan Negative Regulation Of Cell Adhesion Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Macrophage Activation Response To Protozoan Cellular Response To Organic Substance Lymphocyte Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Immune Response Regulation Of T-helper Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Adaptive Immune Response Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Leukocyte Differentiation Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cytokine Production Negative Regulation Of Immune System Process Regulation Of Chemokine Production Regulation Of B Cell Proliferation Lymphocyte Activation Regulation Of Osteoclast Differentiation Immune Response Signal Transduction	Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Regulation Of Proton Transport Microglial Cell Activation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Activation Macrophage Activation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of B Cell Proliferation Positive Regulation Of JAK-STAT Cascade Positive Regulation Of B Cell Activation Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Ethanol Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Positive Regulation Of Eosinophil Chemotaxis Connective Tissue Growth Factor Biosynthetic Process T-helper 2 Cell Cytokine Production Positive Regulation Of Cell Activation Positive Regulation Of Mononuclear Cell Migration Negative Regulation Of NAD(P)H Oxidase Activity B Cell Costimulation Cellular Response To Mercury Ion CD4-positive, Alpha-beta T Cell Cytokine Production Positive Regulation Of Eosinophil Migration Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process T-helper 2 Cell Differentiation Regulation Of Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Chronic Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Macrophage Activation
Tagcloud ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	adenocarcinoma adenocarcinomas antigens applications broadens carcinomas complementary concordant ct distinctly expressed family immunotherapeutic lung member members nontumor particular searched spectrum squamous subset syce1 testes testis vcx vcx3a xage1 y
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	adenocarcinoma adenocarcinomas antigens applications broadens carcinomas complementary concordant ct distinctly expressed family immunotherapeutic lung member members nontumor particular searched spectrum squamous subset syce1 testes testis vcx vcx3a xage1 y
Tagcloud (Intersection) ?