S100P and IL27

Number of citations of the paper that reports this interaction (PubMedID 36233301)
61

Data Source:
BioGRID (pull down)

		S100P	IL27
Description		S100 calcium binding protein P	interleukin 27
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol Cell Surface
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Endothelial Cell Migration	Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Signal Transduction Response To Bacterium Positive Regulation Of Type II Interferon Production Regulation Of T Cell Proliferation Innate Immune Response Regulation Of T-helper 1 Cell Differentiation Regulation Of Defense Response To Virus Regulation Of T Cell Activation Response To Gram-positive Bacterium
Pathways		Neutrophil degranulation	Interleukin-27 signaling Interleukin-27 signaling
Drugs		Cromoglicic acid
Diseases
GWAS		Obesity-related traits ( 23251661)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Ankylosing spondylitis ( 23749187) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28892062) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 28166215) Crohn's disease ( 28067908 30500874 32581322 21102463) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 1 diabetes ( 25751624 21829393 19430480)
Interacting Genes		46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A	3 interacting genes: IL27RA S100A6 S100P
Entrez ID		6286	246778
HPRD ID		02792	16307
Ensembl ID		ENSG00000163993	ENSG00000197272
Uniprot IDs		P25815	Q8NEV9
PDB IDs		1J55 1OZO 2MJW 7NMI	7U7N 7ZXK 8D85 8XWY
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation	Calcium-dependent Protein Binding Negative Regulation Of T Cell Extravasation Interleukin-27 Receptor Activity Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Transition Metal Ion Binding Negative Regulation Of Lymphocyte Migration Negative Regulation Of Interleukin-17 Production Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Migration Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Cellular Extravasation Negative Regulation Of Type 2 Immune Response Calcium Ion Binding Protein Homodimerization Activity Microvillus Membrane Regulation Of Isotype Switching Regulation Of Type 2 Immune Response Regulation Of T-helper 17 Type Immune Response Regulation Of Cellular Extravasation Negative Regulation Of Mononuclear Cell Migration
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