IL13 and IL4R

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IL13	IL4R
Description		interleukin 13	interleukin 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-13 Receptor Binding Protein Binding	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Response To Mechanical Stimulus Response To Nematode Regulation Of Proton Transport Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Transforming Growth Factor Beta1 Production Response To Nicotine Interleukin-13-mediated Signaling Pathway Macrophage Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		Cintredekin besudotox Lebrikizumab Lebrikizumab Dupilumab Tralokinumab Romilkimab	AER001 Dupilumab
Diseases		Graft-versus-host disease Asthma	Asthma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 20860503 34103634 32296059 31959851 31619474 31361310 29785011 29273806) Asthma (childhood onset) ( 24241537 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879 25574825 23727859 23886662) Childhood asthma with severe exacerbations ( 33328473) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 22286212 24920014) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Lymphocyte count ( 32888494) Psoriasis ( 25574825 19169254 23143594 25903422) Psoriasis vulgaris ( 26626624) Rosacea symptom severity ( 29771307)	Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		8 interacting genes: CFTR IL13RA1 IL13RA2 IL4R PIK3R1 S100A6 S100P VCAM1	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3596	3566
HPRD ID		00981	00990
Ensembl ID		ENSG00000169194	ENSG00000077238
Uniprot IDs		P35225 Q4VB53	B2RBY1 P24394
PDB IDs		1GA3 1IJZ 1IK0 3BPO 3G6D 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y 8BLQ	1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
Enriched GO Terms of Interacting Partners?		Cytokine Receptor Activity Regulation Of Immunoglobulin Production External Side Of Plasma Membrane Plasma Membrane Cytokine-mediated Signaling Pathway Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Regulation Of Exocytosis Regulation Of Production Of Molecular Mediator Of Immune Response Receptor Complex Regulation Of Mast Cell Degranulation T-helper Cell Differentiation Immunoglobulin Mediated Immune Response Lymphocyte Differentiation Cytokine Binding T Cell Differentiation Involved In Immune Response B Cell Mediated Immunity CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Immune System Process CD4-positive, Alpha-beta T Cell Activation Mononuclear Cell Differentiation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Alpha-beta T Cell Differentiation Interleukin-13 Receptor Complex Positive Regulation Of Cell Population Proliferation Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation T Cell Activation Involved In Immune Response Leukocyte Differentiation Calcium-dependent Protein Binding Immune Effector Process Membrane Positive Regulation Of Exocytosis Membrane Docking Positive Regulation Of Immune System Process Positive Regulation Of Anion Channel Activity Alpha-beta T Cell Activation Interleukin-4 Receptor Activity Peripheral Nervous System Neuron Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Activation Extracellular Region B Cell Differentiation Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Hemopoiesis Lymphocyte Activation Involved In Immune Response Interleukin-13-mediated Signaling Pathway	Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?