S100P and THPO

Number of citations of the paper that reports this interaction (PubMedID 36233301)
61

Data Source:
BioGRID (pull down)

		S100P	THPO
Description		S100 calcium binding protein P	thrombopoietin
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Endothelial Cell Migration	Positive Regulation Of Protein Phosphorylation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Neutrophil degranulation	Platelet Aggregation (Plug Formation)
Drugs		Cromoglicic acid
Diseases
GWAS		Obesity-related traits ( 23251661)	Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A	6 interacting genes: APH1A EP300 MPL NUMBL S100A6 S100P
Entrez ID		6286	7066
HPRD ID		02792	02500
Ensembl ID		ENSG00000163993	ENSG00000090534
Uniprot IDs		P25815	A0A3B3ITS0 F8W6L1 P40225 Q5FBX8
PDB IDs		1J55 1OZO 2MJW 7NMI	1V7M 1V7N 8G04
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation	Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Platelet Formation Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Positive Regulation Of Cell Development Histone Crotonyltransferase Activity Basophil Homeostasis Thrombopoietin Receptor Activity Calcium-dependent Protein Binding Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Platelet Formation N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Monocyte Homeostasis Eosinophil Homeostasis Neuroblast Division In Subventricular Zone Axonogenesis Negative Regulation Of Protein Oligomerization Regulation Of Cell Development L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Tubulin Deacetylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Thrombopoietin-mediated Signaling Pathway Gamma-secretase Complex Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Response To Hypoxia Myeloid Cell Differentiation Peptidyl-lysine Acetylation
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