S100P and PRL

Number of citations of the paper that reports this interaction (PubMedID 36233301)
61

Data Source:
BioGRID (pull down)

		S100P	PRL
Description		S100 calcium binding protein P	prolactin
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome	Extracellular Region Extracellular Space Endosome Lumen Vesicle
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding	Prolactin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Endothelial Cell Migration	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Prolactin Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MiRNA Transcription Positive Regulation Of Lactation
Pathways		Neutrophil degranulation	Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Cromoglicic acid
Diseases
GWAS		Obesity-related traits ( 23251661)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278)
Interacting Genes		46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A	6 interacting genes: MEOX2 PPIB PRLR S100A6 S100P UBQLN4
Entrez ID		6286	5617
HPRD ID		02792	07180
Ensembl ID		ENSG00000163993	ENSG00000172179
Uniprot IDs		P25815	P01236 Q5I0G2 Q5THQ0
PDB IDs		1J55 1OZO 2MJW 7NMI	1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation	Positive Regulation Of Sphingolipid Mediated Signaling Pathway Endothelial Cell Migration Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling Lipopolysaccharide Transport Prolactin Receptor Activity Calcium-dependent Protein Binding Nuclear Proteasome Complex Positive Regulation Of Nitric Oxide Mediated Signal Transduction Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Regulation Of Phosphatidylcholine Catabolic Process Somite Specification Perinuclear Region Of Cytoplasm Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Autophagosome Maturation Cytosolic Proteasome Complex
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