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IL13
Description
interleukin 13
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
External Side Of Plasma Membrane
Molecular Function
Cytokine Activity
Cytokine Receptor Binding
Interleukin-13 Receptor Binding
Protein Binding
Biological Process
Microglial Cell Activation
Positive Regulation Of Immunoglobulin Production
Inflammatory Response
Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Mechanical Stimulus
Response To Nematode
Regulation Of Proton Transport
Response To Selenium Ion
Positive Regulation Of Gene Expression
Positive Regulation Of B Cell Proliferation
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-10 Production
Transforming Growth Factor Beta1 Production
Response To Nicotine
Interleukin-13-mediated Signaling Pathway
Macrophage Activation
Positive Regulation Of Macrophage Activation
Positive Regulation Of Monoatomic Ion Transport
Positive Regulation Of Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Protein Secretion
Negative Regulation Of Inflammatory Response
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Mechanical Stimulus
Cellular Response To Cytokine Stimulus
Negative Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Lung Ciliated Cell Differentiation
Positive Regulation Of Lung Goblet Cell Differentiation
Negative Regulation Of Complement-dependent Cytotoxicity
Positive Regulation Of Pancreatic Stellate Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
Drugs
Cintredekin besudotox
Lebrikizumab
Lebrikizumab
Dupilumab
Tralokinumab
Romilkimab
Diseases
Graft-versus-host disease
Asthma
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Allergy (
27182965
)
Alopecia areata (
25608926
)
Asthma (
20860503
34103634
32296059
31959851
31619474
31361310
29785011
29273806
)
Asthma (childhood onset) (
24241537
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
23042114
26482879
25574825
23727859
23886662
)
Childhood asthma with severe exacerbations (
33328473
)
Cutaneous psoriasis (
26626624
)
Hodgkin's lymphoma (
22286212
24920014
)
IgE levels (
22075330
)
Inflammatory bowel disease (
23128233
)
Lymphocyte count (
32888494
)
Psoriasis (
25574825
19169254
23143594
25903422
)
Psoriasis vulgaris (
26626624
)
Rosacea symptom severity (
29771307
)
Interacting Genes
8 interacting genes:
CFTR
IL13RA1
IL13RA2
IL4R
PIK3R1
S100A6
S100P
VCAM1
Entrez ID
3596
HPRD ID
00981
Ensembl ID
ENSG00000169194
Uniprot IDs
P35225
Q4VB53
PDB IDs
1GA3
1IJZ
1IK0
3BPO
3G6D
3L5W
3L5X
3LB6
4I77
4PS4
5E4E
5L6Y
8BLQ
Enriched GO Terms of Interacting Partners
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Cytokine Receptor Activity
Regulation Of Immunoglobulin Production
External Side Of Plasma Membrane
Plasma Membrane
Cytokine-mediated Signaling Pathway
Lymphocyte Mediated Immunity
Leukocyte Mediated Immunity
Regulation Of Exocytosis
Regulation Of Production Of Molecular Mediator Of Immune Response
Receptor Complex
Regulation Of Mast Cell Degranulation
T-helper Cell Differentiation
Immunoglobulin Mediated Immune Response
Lymphocyte Differentiation
Cytokine Binding
T Cell Differentiation Involved In Immune Response
B Cell Mediated Immunity
CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of Immunoglobulin Production
Regulation Of Immune System Process
CD4-positive, Alpha-beta T Cell Activation
Mononuclear Cell Differentiation
Intracellularly ATP-gated Chloride Channel Activity
Positive Regulation Of Voltage-gated Chloride Channel Activity
Sec61 Translocon Complex Binding
Alpha-beta T Cell Differentiation
Interleukin-13 Receptor Complex
Positive Regulation Of Cell Population Proliferation
Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
Cardiac Neuron Differentiation
T Cell Activation Involved In Immune Response
Leukocyte Differentiation
Calcium-dependent Protein Binding
Immune Effector Process
Membrane
Positive Regulation Of Exocytosis
Membrane Docking
Positive Regulation Of Immune System Process
Positive Regulation Of Anion Channel Activity
Alpha-beta T Cell Activation
Interleukin-4 Receptor Activity
Peripheral Nervous System Neuron Differentiation
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Lymphocyte Activation
Extracellular Region
B Cell Differentiation
Positive Regulation Of Monoatomic Anion Transport
Negative Regulation Of Hemopoiesis
Lymphocyte Activation Involved In Immune Response
Interleukin-13-mediated Signaling Pathway
Tagcloud
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