IL13

Name	interleukin 13
Structure
Interactors	8 interactors: CFTR IL13RA1 IL13RA2 IL4R PIK3R1 S100A6 S100P VCAM1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-13 Receptor Binding Protein Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Response To Mechanical Stimulus Response To Nematode Regulation Of Proton Transport Response To Selenium Ion Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Transforming Growth Factor Beta1 Production Response To Nicotine Interleukin-13-mediated Signaling Pathway Macrophage Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs	Cintredekin besudotox Lebrikizumab Lebrikizumab Dupilumab Tralokinumab Romilkimab
Diseases	Graft-versus-host disease Asthma
GWAS	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 30013184 ) Allergy ( 27182965 ) Alopecia areata ( 25608926 ) Asthma ( 20860503 34103634 32296059 31959851 31619474 31361310 29785011 29273806 ) Asthma (childhood onset) ( 24241537 29273806 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 23042114 26482879 25574825 23727859 23886662 ) Childhood asthma with severe exacerbations ( 33328473 ) Cutaneous psoriasis ( 26626624 ) Hodgkin's lymphoma ( 22286212 24920014 ) IgE levels ( 22075330 ) Inflammatory bowel disease ( 23128233 ) Lymphocyte count ( 32888494 ) Psoriasis ( 25574825 19169254 23143594 25903422 ) Psoriasis vulgaris ( 26626624 ) Rosacea symptom severity ( 29771307 )
Entrez ID	3596
HPRD ID	00981
Ensembl ID	ENSG00000169194
Uniprot IDs	P35225 Q4VB53
PDB IDs	1GA3 1IJZ 1IK0 3BPO 3G6D 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y 8BLQ
GO Terms Enriched among Interactors ?	Cytokine Receptor Activity Regulation Of Immunoglobulin Production External Side Of Plasma Membrane Plasma Membrane Cytokine-mediated Signaling Pathway Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Regulation Of Exocytosis Regulation Of Production Of Molecular Mediator Of Immune Response Receptor Complex Regulation Of Mast Cell Degranulation T-helper Cell Differentiation Immunoglobulin Mediated Immune Response Lymphocyte Differentiation Cytokine Binding T Cell Differentiation Involved In Immune Response B Cell Mediated Immunity CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of Immune System Process CD4-positive, Alpha-beta T Cell Activation Mononuclear Cell Differentiation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Alpha-beta T Cell Differentiation Interleukin-13 Receptor Complex Positive Regulation Of Cell Population Proliferation Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation T Cell Activation Involved In Immune Response Leukocyte Differentiation Calcium-dependent Protein Binding Immune Effector Process Membrane Positive Regulation Of Exocytosis Membrane Docking Positive Regulation Of Immune System Process Positive Regulation Of Anion Channel Activity Alpha-beta T Cell Activation Interleukin-4 Receptor Activity Peripheral Nervous System Neuron Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Lymphocyte Activation Extracellular Region B Cell Differentiation Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Hemopoiesis Lymphocyte Activation Involved In Immune Response Interleukin-13-mediated Signaling Pathway