IL6ST and KCNIP3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		IL6ST	KCNIP3
Gene Name		interleukin 6 signal transducer	Kv channel interacting protein 3, calsenilin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Ciliary Neurotrophic Factor Receptor Complex	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Interleukin-27 Receptor Activity	DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein C-terminus Binding Potassium Channel Regulator Activity Sequence-specific DNA Binding Ion Channel Binding Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Protein Transport Apoptotic Process Signal Transduction Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Regulation Of Neuron Apoptotic Process Behavioral Response To Pain Potassium Ion Transmembrane Transport
Pathways		Signaling by Interleukins Interleukin-6 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		31 interactors: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1	17 interactors: ADRBK1 CALM2 CASP3 CD177 CLN3 CREB1 CREM GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2
Entrez ID		3572	30818
HPRD ID		02824	05232
Ensembl ID		ENSG00000134352	ENSG00000115041
Uniprot IDs		D6RH03 P40189 Q17RA0	Q9Y2W7
PDB IDs		1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J	2E6W
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Organic Substance Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Cell Proliferation Cell Communication Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Regulation Of Cellular Ketone Metabolic Process Leukocyte Migration Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Regulation Of JAK-STAT Cascade	Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Negative Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Amyloid Precursor Protein Metabolic Process Regulation Of Protein Phosphorylation Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Phosphorylation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Activation Of Phospholipase C Activity Negative Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Regulation Of Kinase Activity Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Response To Stress Negative Regulation Of Kinase Activity Protein Processing Negative Regulation Of Apoptotic Process Positive Regulation Of Phospholipase Activity Negative Regulation Of Programmed Cell Death Learning Or Memory
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
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