IL6ST and KCNIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL6ST	KCNIP1
Description		interleukin 6 cytokine family signal transducer	potassium voltage-gated channel interacting protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Cell Body Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Monoatomic Ion Channel Complex Cell Projection Synapse Kv4.3-KChIP1 Channel Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Coreceptor Activity Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Cell Differentiation Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Membrane Repolarization Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Type 1 diabetes ( 34127860)	Acne (severe) ( 24927181) California verbal learning test score ( 31596458) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Normalized brain volume ( 19010793) Placental abruption ( 29884306) Pre-treatment viral load in HIV-1 infection ( 31219150) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 NEDD4L OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1	16 interacting genes: AMPD3 ASPH CIAO2A DAAM2 IL6ST KCND1 KCND2 KCND3 KCNIP2 LITAF NHLH2 NIF3L1 SOD3 SPP1 SPRED2 TBC1D25
Entrez ID		3572	30820
HPRD ID		02824	06879
Ensembl ID		ENSG00000134352	ENSG00000182132
Uniprot IDs		A0A0A0N0L2 A0A0A0N0L5 A0A8V8TMJ9 A0A8V8TNI4 P40189 Q17RA0	Q9NZI2
PDB IDs		1BJ8 1BQU 1I1R 1P9M 1PVH 3L5H 3L5I 3L5J 7U7N 8D6A 8D74 8D7R 8D82 8D85 8DPS 8DPT 8DPU 8UPA 8V29 8V2A	1S1E 2I2R 2NZ0 7E83 7E84 7F3F 7W6N 7W6T
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process T-helper 17 Cell Lineage Commitment Regulation Of Cell Population Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Signal Transduction Interleukin-6-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway T-helper Cell Lineage Commitment Negative Regulation Of Apoptotic Process Interleukin-11-mediated Signaling Pathway Phosphotyrosine Residue Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Alpha-beta T Cell Lineage Commitment Positive Regulation Of Peptidyl-tyrosine Phosphorylation CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Adhesion Regulation Of MAPK Cascade Regulation Of Apoptotic Process T Cell Lineage Commitment Receptor Complex Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Ciliary Neurotrophic Factor Receptor Activity Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Cytokine Receptor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction	A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Kv4.2-KChIP2 Channel Complex Membrane Repolarization Action Potential Monoatomic Ion Channel Complex Regulation Of System Process Potassium Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Potassium Ion Transport Regulation Of Heart Contraction Muscle Contraction Regulation Of Blood Circulation Muscle System Process Detection Of Calcium Ion Metal Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Action Potential Neuronal Cell Body Inorganic Ion Transmembrane Transport Dendritic Spine Postsynaptic Specialization Membrane Regulation Of Multicellular Organismal Process Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Membrane Potential Protein Homooligomerization Dendrite Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Monoatomic Ion Transport Postsynaptic Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Interleukin-27 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Regulation Of Glial Cell Differentiation Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Protein Complex Oligomerization Kv4.3-KChIP1 Channel Complex Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Positive Regulation Of Estradiol Secretion Cytoplasmic Side Of Late Endosome Membrane Metal Ion Binding AMP Deaminase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
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