IL6ST and IL31RA

Number of citations of the paper that reports this interaction (PubMedID 15184896)
0

Data Source:
HPRD (in vivo)

		IL6ST	IL31RA
Description		interleukin 6 cytokine family signal transducer	interleukin 31 receptor A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Cell Body Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Axon Presynaptic Membrane Cell Projection Receptor Complex Synapse
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Coreceptor Activity Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding	Transcription Coactivator Activity Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Cell Differentiation Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation	MAPK Cascade Glandular Epithelial Cell Differentiation Immune System Process Acute Inflammatory Response To Antigenic Stimulus Defense Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Homeostatic Process Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Cell Surface Receptor Signaling Pathway Via STAT Defense Response To Other Organism
Pathways		Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Type 1 diabetes ( 34127860)	Crohn's disease ( 23128233)
Interacting Genes		35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 NEDD4L OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1	2 interacting genes: IL6ST LIFR
Entrez ID		3572	133396
HPRD ID		02824	17145
Ensembl ID		ENSG00000134352	ENSG00000164509
Uniprot IDs		A0A0A0N0L2 A0A0A0N0L5 A0A8V8TMJ9 A0A8V8TNI4 P40189 Q17RA0	B4DNJ2 Q8NI17
PDB IDs		1BJ8 1BQU 1I1R 1P9M 1PVH 3L5H 3L5I 3L5J 7U7N 8D6A 8D74 8D7R 8D82 8D85 8DPS 8DPT 8DPU 8UPA 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process T-helper 17 Cell Lineage Commitment Regulation Of Cell Population Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Signal Transduction Interleukin-6-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway T-helper Cell Lineage Commitment Negative Regulation Of Apoptotic Process Interleukin-11-mediated Signaling Pathway Phosphotyrosine Residue Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Alpha-beta T Cell Lineage Commitment Positive Regulation Of Peptidyl-tyrosine Phosphorylation CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Adhesion Regulation Of MAPK Cascade Regulation Of Apoptotic Process T Cell Lineage Commitment Receptor Complex Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Ciliary Neurotrophic Factor Receptor Activity Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Cytokine Receptor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction	Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding Growth Factor Binding Cytokine Receptor Activity Receptor Complex Interleukin-27 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex External Side Of Plasma Membrane Interleukin-11 Receptor Activity Interleukin-11 Binding Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding Interleukin-27-mediated Signaling Pathway Response To Peptide Response To Cytokine Intestinal Epithelial Cell Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Platelet Aggregation Positive Regulation Of Astrocyte Differentiation T-helper 17 Cell Lineage Commitment Columnar/cuboidal Epithelial Cell Development Protein Tyrosine Kinase Activator Activity Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Cell Population Proliferation Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Platelet Aggregation T Cell Lineage Commitment Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Regulation Of Acute Inflammatory Response
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