IL4R and INPP5D

Number of citations of the paper that reports this interaction (PMID 11714803)
11

Data Source:
HPRD (in vitro, in vivo)

		IL4R	INPP5D
Gene Name		interleukin 4 receptor	inositol polyphosphate-5-phosphatase, 145kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Receptor Complex	Cytosol Membrane
	Molecular Function	Interleukin-4 Receptor Activity Receptor Signaling Protein Activity Protein Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Immune Response Signal Transduction Ovulation Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration
Pathways			Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs
Diseases
GWAS		IgE levels ( 22075330)	Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		22 interactors: ARIH2 CD40 DOK2 FES GNB2L1 HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 SHC1 SOCS5 STAT6	40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17
Entrez ID		3566	3635
HPRD ID		00990	09033
Ensembl ID		ENSG00000077238	ENSG00000168918
Uniprot IDs		B2RBY1 B4E076 P24394	Q92835
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO	2YSX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of B Cell Activation Immune Response Defense Response Cellular Response To Organic Substance Response To Cytokine JAK-STAT Cascade Response To Organic Substance Signal Transduction Regulation Of Signaling Regulation Of B Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Innate Immune Response Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Immunoglobulin Production Epidermal Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Regulation Of Adaptive Immune Response Regulation Of JAK-STAT Cascade Cellular Response To Peptide Regulation Of Phosphorylation Response To Growth Hormone Positive Regulation Of B Cell Proliferation Regulation Of Cellular Localization Regulation Of Kinase Activity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cellular Response To Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?