IL4R and IL13RA2

Number of citations of the paper that reports this interaction (PubMedID 22952195)
64

Data Source:
BioGRID (pull down, pull down)

		IL4R	IL13RA2
Description		interleukin 4 receptor	interleukin 13 receptor subunit alpha 2
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion	Negative Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Transforming Growth Factor Beta1 Production Interleukin-13-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		AER001 Dupilumab	AER001
Diseases		Asthma
GWAS		Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1
Entrez ID		3566	3598
HPRD ID		00990	02132
Ensembl ID		ENSG00000077238	ENSG00000123496
Uniprot IDs		B2RBY1 P24394	Q14627
PDB IDs		1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q	3LB6
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Multicellular Organismal Process Immune System Process Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process ERBB Signaling Pathway Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Animal Organ Development Positive Regulation Of Immune System Process Regulation Of Developmental Process Positive Regulation Of Cold-induced Thermogenesis Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Immune System Process Response To Lipid Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Leukocyte Activation Apoptotic Process Regulation Of Cold-induced Thermogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Locomotion Cell Death Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Developmental Process Defense Response Interleukin-4-mediated Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Activation
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