IL4R and FES

Number of citations of the paper that reports this interaction (PMID 7518439)
6

Data Source:
HPRD (in vivo)

		IL4R	FES
Gene Name		interleukin 4 receptor	FES proto-oncogene, tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Interleukin-4 Receptor Activity Receptor Signaling Protein Activity Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Immune Response Signal Transduction Ovulation Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways			Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		IgE levels ( 22075330)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		22 interactors: ARIH2 CD40 DOK2 FES GNB2L1 HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 SHC1 SOCS5 STAT6	31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID		3566	2242
HPRD ID		00990	01814
Ensembl ID		ENSG00000077238	ENSG00000182511
Uniprot IDs		B2RBY1 B4E076 P24394	P07332
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO	1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of B Cell Activation Immune Response Defense Response Cellular Response To Organic Substance Response To Cytokine JAK-STAT Cascade Response To Organic Substance Signal Transduction Regulation Of Signaling Regulation Of B Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Innate Immune Response Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Immunoglobulin Production Epidermal Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Regulation Of Adaptive Immune Response Regulation Of JAK-STAT Cascade Cellular Response To Peptide Regulation Of Phosphorylation Response To Growth Hormone Positive Regulation Of B Cell Proliferation Regulation Of Cellular Localization Regulation Of Kinase Activity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cellular Response To Stimulus	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?		jak1 jak3