IL4R and IL13RA1

Number of citations of the paper that reports this interaction (PMID 8910586)
35

Data Source:
HPRD (in vivo, in vitro)

		IL4R	IL13RA1
Gene Name		interleukin 4 receptor	interleukin 13 receptor, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Receptor Complex	Plasma Membrane Interleukin-13 Receptor Complex
	Molecular Function	Interleukin-4 Receptor Activity Receptor Signaling Protein Activity Protein Binding	Protein Binding Interleukin-13 Receptor Activity
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Immune Response Signal Transduction Ovulation Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Interleukin-13-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		IgE levels ( 22075330)
Protein-Protein Interactions		22 interactors: ARIH2 CD40 DOK2 FES GNB2L1 HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 SHC1 SOCS5 STAT6	6 interactors: DLG4 IL13 IL4R TMEM39B TRAF3IP1 TYK2
Entrez ID		3566	3597
HPRD ID		00990	02125
Ensembl ID		ENSG00000077238	ENSG00000131724
Uniprot IDs		B2RBY1 B4E076 P24394	P78552
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO	3BPN 3BPO 4HWB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of B Cell Activation Immune Response Defense Response Cellular Response To Organic Substance Response To Cytokine JAK-STAT Cascade Response To Organic Substance Signal Transduction Regulation Of Signaling Regulation Of B Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Innate Immune Response Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Immunoglobulin Production Epidermal Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Regulation Of Adaptive Immune Response Regulation Of JAK-STAT Cascade Cellular Response To Peptide Regulation Of Phosphorylation Response To Growth Hormone Positive Regulation Of B Cell Proliferation Regulation Of Cellular Localization Regulation Of Kinase Activity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cellular Response To Stimulus	Positive Regulation Of Macrophage Activation Regulation Of Macrophage Activation Regulation Of Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Response To Cytokine Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Protein Secretion Negative Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Production Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Regulation Of Signaling Maintenance Of Apical/basal Cell Polarity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Immune Response Positive Regulation Of Cell Activation Receptor Localization To Synapse Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Defense Response Positive Regulation Of Chemokine Secretion Negative Regulation Of Receptor Internalization Positive Regulation Of Secretion Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Protein Transport Negative Regulation Of T-helper Cell Differentiation Locomotory Exploration Behavior Regulation Of Cell Proliferation Positive Regulation Of Cytokine Production Dendritic Spine Morphogenesis Negative Regulation Of Immune System Process Synaptic Vesicle Maturation Interleukin-4-mediated Signaling Pathway Maintenance Of Cell Polarity Regulation Of Lymphocyte Activation Regulation Of Proton Transport Regulation Of Protein Secretion Negative Regulation Of Alpha-beta T Cell Differentiation Microglial Cell Activation
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	1b aiming balance bearing ccl24 clec4a2 decline delta depends elucidating eotaxin fold gm h37rv hour il12b immunological inb1 initiated mce1 microarrays plex post ppargamma pro qpcr switch tuberculosis uninfected
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	1b aiming balance bearing ccl24 clec4a2 decline delta depends elucidating eotaxin fold gm h37rv hour il12b immunological inb1 initiated mce1 microarrays plex post ppargamma pro qpcr switch tuberculosis uninfected
Tagcloud (Intersection) ?