IL4R and IL13

Number of citations of the paper that reports this interaction (PMID 11709756)
63

Data Source:
HPRD (in vivo)

		IL4R	IL13
Gene Name		interleukin 4 receptor	interleukin 13
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Interleukin-4 Receptor Activity Receptor Signaling Protein Activity Protein Binding	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Immune Response Signal Transduction Ovulation Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Regulation Of Proton Transport Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Positive Regulation Of Macrophage Activation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS		IgE levels ( 22075330)	Asthma ( 20860503) Atopic dermatitis ( 23042114) Hodgkin's lymphoma ( 22286212) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Psoriasis ( 19169254)
Protein-Protein Interactions		22 interactors: ARIH2 CD40 DOK2 FES GNB2L1 HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 SHC1 SOCS5 STAT6	6 interactors: IL13RA1 IL13RA2 IL4 IL4R PIK3R1 VCAM1
Entrez ID		3566	3596
HPRD ID		00990	00981
Ensembl ID		ENSG00000077238	ENSG00000169194
Uniprot IDs		B2RBY1 B4E076 P24394	P35225
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3L5Y 3LB6 4I77
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of B Cell Activation Immune Response Defense Response Cellular Response To Organic Substance Response To Cytokine JAK-STAT Cascade Response To Organic Substance Signal Transduction Regulation Of Signaling Regulation Of B Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Innate Immune Response Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Immunoglobulin Production Epidermal Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Regulation Of Adaptive Immune Response Regulation Of JAK-STAT Cascade Cellular Response To Peptide Regulation Of Phosphorylation Response To Growth Hormone Positive Regulation Of B Cell Proliferation Regulation Of Cellular Localization Regulation Of Kinase Activity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cellular Response To Stimulus	Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Cytokine Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion B Cell Differentiation Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of T-helper Cell Differentiation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Immune System Process Negative Regulation Of Alpha-beta T Cell Differentiation Cellular Response To Cytokine Stimulus B Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Defense Response To Protozoan Negative Regulation Of Cell Adhesion Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Macrophage Activation Response To Protozoan Cellular Response To Organic Substance Lymphocyte Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Immune Response Regulation Of T-helper Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Adaptive Immune Response Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Leukocyte Differentiation Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cytokine Production Negative Regulation Of Immune System Process Regulation Of Chemokine Production Regulation Of B Cell Proliferation Lymphocyte Activation Regulation Of Osteoclast Differentiation Immune Response Signal Transduction
Tagcloud ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?		4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous	30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Intersection) ?		il2 il4