IL4 and A2M

Number of citations of the paper that reports this interaction (PMID 10714547)
5

Data Source:
BioGRID (pull down)

		IL4	A2M
Gene Name		interleukin 4	alpha-2-macroglobulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host T-helper 1 Cell Lineage Commitment Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Chemotaxis Immune Response Cellular Defense Response Female Pregnancy Response To Nutrient Cholesterol Metabolic Process Regulation Of Proton Transport Response To Organic Cyclic Compound B Cell Differentiation Positive Regulation Of B Cell Proliferation B Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Response To Cytokine T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation B Cell Activation Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Biosynthetic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Mercury Ion Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: A2M CD53 IL13 IL13RA2 IL2RG IL4R PIK3CD	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		3565	2
HPRD ID		00989	00072
Ensembl ID		ENSG00000113520	ENSG00000175899
Uniprot IDs		D4HNR6 P05112 Q5FC01	P01023
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Activation Interleukin-4-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Macrophage Activation Response To Cytokine Signal Transduction Signaling Cell Communication Cellular Response To Organic Substance Cellular Response To Interleukin-4 Response To Interleukin-4 Cellular Response To Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Response To Organic Substance Immune Response Regulation Of Immune System Process Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Immune Response Response To Stimulus Cell Activation Negative Regulation Of T-helper 1 Cell Differentiation Mast Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Natural Killer Cell Chemotaxis B Cell Chemotaxis Neutrophil Extravasation Interleukin-2-mediated Signaling Pathway Mast Cell Chemotaxis Positive Regulation Of Protein Secretion Respiratory Burst Involved In Defense Response Positive Regulation Of Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Immune System Process Immune System Process Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Chemokine Secretion Regulation Of T-helper 1 Cell Differentiation T Cell Chemotaxis Negative Regulation Of T-helper Cell Differentiation	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?