IL4 and IL4R

Number of citations of the paper that reports this interaction (PubMedID 11786020)
0

Data Source:
HPRD (in vivo, in vitro)

		IL4	IL4R
Description		interleukin 4	interleukin 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy B Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Interleukin-4-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Macrophage Activation Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Isotype Switching Leukocyte Activation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of ATP Biosynthetic Process	Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		Pascolizumab Dupilumab Romilkimab	AER001 Dupilumab
Diseases		Asthma	Asthma
GWAS		Asthma ( 29273806 31619474 31959851) Asthma (childhood onset) ( 29273806 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278)	Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3565	3566
HPRD ID		00989	00990
Ensembl ID		ENSG00000113520	ENSG00000077238
Uniprot IDs		D4HNR6 P05112 Q5FC01 U3LVN1	B2RBY1 P24394
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL 8A4F 8CGF 8CH7	1IAR 1IRS 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL 8K4Q
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Interleukin-4 Receptor Activity Negative Regulation Of Immune System Process Cytokine Receptor Activity Lymphocyte Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Immunoglobulin Production Mononuclear Cell Differentiation Leukocyte Differentiation Negative Regulation Of Hemopoiesis Positive Regulation Of Myoblast Fusion Regulation Of Hemopoiesis Lymphocyte Activation Leukocyte Mediated Immunity Regulation Of Myoblast Fusion Immune System Process T Cell Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Lymphocyte Activation Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Activation Receptor Complex Regulation Of Mast Cell Degranulation Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Cell Activation Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Immunoglobulin Mediated Immune Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cytokine Binding Positive Regulation Of T Cell Activation B Cell Mediated Immunity Negative Regulation Of Cell Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Activation Adaptive Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Cell Development Negative Regulation Of Lymphocyte Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Alpha-beta T Cell Differentiation Cellular Developmental Process	Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Activation Interleukin-4-mediated Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of B Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Positive Regulation Of B Cell Activation Positive Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Immunoglobulin Production Regulation Of Multicellular Organismal Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Adaptive Immune Response Signal Transduction Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cytokine Production Insulin Receptor Binding Regulation Of Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell-cell Adhesion Regulation Of B Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Leukocyte Activation Positive Regulation Of T Cell Activation Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Type 2 Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Hemopoiesis Regulation Of Macromolecule Biosynthetic Process
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