IL4 and IL2RG

Number of citations of the paper that reports this interaction (PMID 8266078)
123

Data Source:
HPRD (in vivo)

		IL4	IL2RG
Gene Name		interleukin 4	interleukin 2 receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding
	Biological Process	Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host T-helper 1 Cell Lineage Commitment Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Chemotaxis Immune Response Cellular Defense Response Female Pregnancy Response To Nutrient Cholesterol Metabolic Process Regulation Of Proton Transport Response To Organic Cyclic Compound B Cell Differentiation Positive Regulation Of B Cell Proliferation B Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Response To Cytokine T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation B Cell Activation Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Biosynthetic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Mercury Ion Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway
Pathways			Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: A2M CD53 IL13 IL13RA2 IL2RG IL4R PIK3CD	24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3565	3561
HPRD ID		00989	02391
Ensembl ID		ENSG00000113520	ENSG00000147168
Uniprot IDs		D4HNR6 P05112 Q5FC01	P31785 Q5FC09
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Activation Interleukin-4-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Macrophage Activation Response To Cytokine Signal Transduction Signaling Cell Communication Cellular Response To Organic Substance Cellular Response To Interleukin-4 Response To Interleukin-4 Cellular Response To Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Response To Organic Substance Immune Response Regulation Of Immune System Process Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Immune Response Response To Stimulus Cell Activation Negative Regulation Of T-helper 1 Cell Differentiation Mast Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Natural Killer Cell Chemotaxis B Cell Chemotaxis Neutrophil Extravasation Interleukin-2-mediated Signaling Pathway Mast Cell Chemotaxis Positive Regulation Of Protein Secretion Respiratory Burst Involved In Defense Response Positive Regulation Of Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Immune System Process Immune System Process Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Chemokine Secretion Regulation Of T-helper 1 Cell Differentiation T Cell Chemotaxis Negative Regulation Of T-helper Cell Differentiation	Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus
Tagcloud ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?