IL4 and IL13RA2

Number of citations of the paper that reports this interaction (PMID 9130652)
11

Data Source:
HPRD (in vivo, in vitro)

		IL4	IL13RA2
Gene Name		interleukin 4	interleukin 13 receptor, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane	Extracellular Space Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Signal Transducer Activity Cytokine Receptor Activity
	Biological Process	Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host T-helper 1 Cell Lineage Commitment Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Chemotaxis Immune Response Cellular Defense Response Female Pregnancy Response To Nutrient Cholesterol Metabolic Process Regulation Of Proton Transport Response To Organic Cyclic Compound B Cell Differentiation Positive Regulation Of B Cell Proliferation B Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Response To Cytokine T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation B Cell Activation Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Biosynthetic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Mercury Ion Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Cytokine-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: A2M CD53 IL13 IL13RA2 IL2RG IL4R PIK3CD	2 interactors: IL13 IL4
Entrez ID		3565	3598
HPRD ID		00989	02132
Ensembl ID		ENSG00000113520	ENSG00000123496
Uniprot IDs		D4HNR6 P05112 Q5FC01	Q14627
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7	3LB6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Activation Interleukin-4-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Macrophage Activation Response To Cytokine Signal Transduction Signaling Cell Communication Cellular Response To Organic Substance Cellular Response To Interleukin-4 Response To Interleukin-4 Cellular Response To Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Response To Organic Substance Immune Response Regulation Of Immune System Process Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Immune Response Response To Stimulus Cell Activation Negative Regulation Of T-helper 1 Cell Differentiation Mast Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Natural Killer Cell Chemotaxis B Cell Chemotaxis Neutrophil Extravasation Interleukin-2-mediated Signaling Pathway Mast Cell Chemotaxis Positive Regulation Of Protein Secretion Respiratory Burst Involved In Defense Response Positive Regulation Of Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Immune System Process Immune System Process Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Chemokine Secretion Regulation Of T-helper 1 Cell Differentiation T Cell Chemotaxis Negative Regulation Of T-helper Cell Differentiation	Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Regulation Of Proton Transport Microglial Cell Activation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Activation Macrophage Activation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of B Cell Proliferation Positive Regulation Of JAK-STAT Cascade Positive Regulation Of B Cell Activation Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Ethanol Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Positive Regulation Of Eosinophil Chemotaxis Connective Tissue Growth Factor Biosynthetic Process T-helper 2 Cell Cytokine Production Positive Regulation Of Cell Activation Positive Regulation Of Mononuclear Cell Migration Negative Regulation Of NAD(P)H Oxidase Activity B Cell Costimulation Cellular Response To Mercury Ion CD4-positive, Alpha-beta T Cell Cytokine Production Positive Regulation Of Eosinophil Migration Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process T-helper 2 Cell Differentiation Regulation Of Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Chronic Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Macrophage Activation
Tagcloud ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	adenocarcinoma adenocarcinomas antigens applications broadens carcinomas complementary concordant ct distinctly expressed family immunotherapeutic lung member members nontumor particular searched spectrum squamous subset syce1 testes testis vcx vcx3a xage1 y
Tagcloud (Difference) ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	adenocarcinoma adenocarcinomas antigens applications broadens carcinomas complementary concordant ct distinctly expressed family immunotherapeutic lung member members nontumor particular searched spectrum squamous subset syce1 testes testis vcx vcx3a xage1 y
Tagcloud (Intersection) ?