IL2 and NGFR

Number of citations of the paper that reports this interaction (PubMedID 1316918)
0

Data Source:
HPRD (in vitro)

		IL2	NGFR
Description		interleukin 2	nerve growth factor receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse
	Molecular Function	Cytokine Activity Interleukin-2 Receptor Binding Protein Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Transcription By RNA Polymerase II Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Gene Expression Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Interleukin-2-mediated Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Plasma Cell Differentiation Response To Tacrolimus Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling	Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs		Pseudoephedrine Cefazolin SP4160 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid SP2456 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide Keyhole limpet hemocyanin Girentuximab TG4010
Diseases		Graft-versus-host disease Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 25608926 20596022) Asthma ( 31619474 31361310 31959851 30929738) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 23727859 26482879) Bipolar disorder ( 31043756) Celiac disease ( 24999842 25920553 22057235 20190752 17558408 18311140) Crohn's disease ( 28067908) Eosinophil count ( 32888494) IgE grass sensitization ( 22036096) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (adrenergics, inhalants) ( 31015401) Primary sclerosing cholangitis ( 27992413 23603763) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 19430480 21829393 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)	Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		9 interacting genes: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR S100A6 SHC1	50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274
Entrez ID		3558	4804
HPRD ID		00979	01197
Ensembl ID		ENSG00000109471	ENSG00000064300
Uniprot IDs		P60568 Q0GK43	P08138
PDB IDs		1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU 6YE3 7DR4 7M2G 7RA9 7RAA 7YZJ 7ZMZ 8SOW 8SOZ 8WYR 8WYS	2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T
Enriched GO Terms of Interacting Partners?		Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2-mediated Signaling Pathway Interleukin-2 Receptor Complex Interleukin-15 Receptor Activity Cell Surface Receptor Signaling Pathway Coreceptor Activity Interleukin-15-mediated Signaling Pathway Signal Transduction Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Cytokine Receptor Activity Positive Regulation Of Developmental Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Animal Organ Morphogenesis Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation External Side Of Plasma Membrane Positive Regulation Of Phagocytosis Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Intracellular Glucose Homeostasis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Development Corticotropin Hormone Secreting Cell Differentiation	Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?