IL2 and FOXK2

Number of citations of the paper that reports this interaction (PMID 9065434)
7

Data Source:
HPRD (in vitro)

		IL2	FOXK2
Gene Name		interleukin 2	forkhead box K2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Activity Interleukin-2 Receptor Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding	Magnesium Ion Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of B Cell Apoptotic Process Immune Response Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		SP4160 5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One (R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester (1h-Indol-3-Yl)-(2-Mercapto-Ethoxyimino)-Acetic Acid SP2456 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752 17558408 18311140) IgE grass sensitization ( 22036096) Inflammatory bowel disease ( 23128233) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480) Type 1 diabetes autoantibodies ( 21829393) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		8 interactors: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR SHC1	2 interactors: IL2 IRF2
Entrez ID		3558	3607
HPRD ID		00979	00982
Ensembl ID			ENSG00000141568
Uniprot IDs		P60568 Q0GK43	Q01167
PDB IDs		1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1	1JXS 2C6Y
Enriched GO Terms of Interacting Partners?		Interleukin-2-mediated Signaling Pathway Response To Interleukin-2 Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Organic Substance Response To Cytokine Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response Interleukin-7-mediated Signaling Pathway Cellular Response To Stimulus Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Hair Follicle Development Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Activation-induced Cell Death Of T Cells Positive Regulation Of Cell Differentiation Regulation Of Immune Response Neurotrophin Signaling Pathway Response To Stimulus Immune System Process Positive Regulation Of Odontogenesis Interleukin-4-mediated Signaling Pathway Regulation Of Cellular Process	Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Heart Contraction Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Isotype Switching Positive Regulation Of Dendritic Spine Development Positive Regulation Of Tissue Remodeling Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Dendritic Spine Development Positive Regulation Of Macromolecule Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Interferon-gamma Production Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of B Cell Proliferation Positive Regulation Of Dendrite Development Natural Killer Cell Activation Positive Regulation Of JAK-STAT Cascade Regulation Of Lymphocyte Apoptotic Process Regulation Of Tissue Remodeling Regulation Of DNA Recombination Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Positive Regulation Of B Cell Activation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of Interferon-gamma Production Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		aberrant accordance address authors autosomal cartilage cd25 cd45ra chh defective define dwarfism explained g0 hair hypoplasia imbalance immunodeficiency immunological limbed naive pha phytohaemagglutinin precisely proliferative recessive restored solely subsets	attenuation bcl2 brdu compensating dramatic emphasized forkhead gadd45alpha gadd45gamma gadd45s inc indicative iodide knockdown noxa p70s6k partly periodicals physiol potentiated propidium puma rapamycin requirement synergistically tgfbeta ubiquitously upregulating wiley
Tagcloud (Difference) ?		aberrant accordance address authors autosomal cartilage cd25 cd45ra chh defective define dwarfism explained g0 hair hypoplasia imbalance immunodeficiency immunological limbed naive pha phytohaemagglutinin precisely proliferative recessive restored solely subsets	attenuation bcl2 brdu compensating dramatic emphasized forkhead gadd45alpha gadd45gamma gadd45s inc indicative iodide knockdown noxa p70s6k partly periodicals physiol potentiated propidium puma rapamycin requirement synergistically tgfbeta ubiquitously upregulating wiley
Tagcloud (Intersection) ?