IL2 and IFNA1

Number of citations of the paper that reports this interaction (PMID 3262520)
2

Data Source:
HPRD (in vitro)

		IL2	IFNA1
Gene Name		interleukin 2	interferon, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-2 Receptor Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding	Cytokine Activity Type I Interferon Receptor Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of B Cell Apoptotic Process Immune Response Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs		SP4160 5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One (R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester (1h-Indol-3-Yl)-(2-Mercapto-Ethoxyimino)-Acetic Acid SP2456 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752 17558408 18311140) IgE grass sensitization ( 22036096) Inflammatory bowel disease ( 23128233) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480) Type 1 diabetes autoantibodies ( 21829393) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		8 interactors: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR SHC1	4 interactors: CR2 IFNAR1 IL2 IRF9
Entrez ID		3558	3439
HPRD ID		00979	00974
Ensembl ID			ENSG00000197919
Uniprot IDs		P60568 Q0GK43	L0N195 P01562
PDB IDs		1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1	3UX9
Enriched GO Terms of Interacting Partners?		Interleukin-2-mediated Signaling Pathway Response To Interleukin-2 Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Organic Substance Response To Cytokine Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response Interleukin-7-mediated Signaling Pathway Cellular Response To Stimulus Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Hair Follicle Development Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Activation-induced Cell Death Of T Cells Positive Regulation Of Cell Differentiation Regulation Of Immune Response Neurotrophin Signaling Pathway Response To Stimulus Immune System Process Positive Regulation Of Odontogenesis Interleukin-4-mediated Signaling Pathway Regulation Of Cellular Process	Type I Interferon Biosynthetic Process Type I Interferon Production Cytokine Biosynthetic Process Immune Response Cytokine Metabolic Process Lymphocyte Activation Positive Regulation Of Interferon-gamma Production Leukocyte Activation Immune System Process Regulation Of Interferon-gamma Production Cell Activation Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Regulation Of Immune Response Cytokine Production Defense Response To Virus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Secretion Regulation Of T Cell Homeostatic Proliferation Lymphocyte Differentiation Regulation Of Immune System Process Defense Response Response To Virus Complement Receptor Mediated Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Regulatory T Cell Differentiation Leukocyte Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Regulation Of Protein Secretion Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immunoglobulin Secretion Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process
Tagcloud ?		aberrant accordance address authors autosomal cartilage cd25 cd45ra chh defective define dwarfism explained g0 hair hypoplasia imbalance immunodeficiency immunological limbed naive pha phytohaemagglutinin precisely proliferative recessive restored solely subsets	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Difference) ?		aberrant accordance address authors autosomal cartilage cd25 cd45ra chh defective define dwarfism explained g0 hair hypoplasia imbalance immunodeficiency immunological limbed naive pha phytohaemagglutinin precisely proliferative recessive restored solely subsets	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Intersection) ?