IFNAR2 and IFNAR1

Number of citations of the paper that reports this interaction (PMID 15389589)
11

Data Source:
HPRD (in vitro)

		IFNAR2	IFNAR1
Gene Name		interferon (alpha, beta and omega) receptor 2	interferon (alpha, beta and omega) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)	Crohn's disease ( 23128233)
Protein-Protein Interactions		14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18	21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70
Entrez ID		3455	3454
HPRD ID		03850	00126
Ensembl ID		ENSG00000159110	ENSG00000142166
Uniprot IDs		P48551 Q9BUA0	B4DNT3 P17181
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	3S98 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels	Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus
Tagcloud ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Difference) ?		aberration aberrations algorithms cgh characterised cin coca confirms custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	adjustment altogether colorectal correction covered czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Intersection) ?		crc