IFNAR2 and STAT2

Number of citations of the paper that reports this interaction (PMID 17923090)
40

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		IFNAR2	STAT2
Gene Name		interferon (alpha, beta and omega) receptor 2	signal transducer and activator of transcription 2, 113kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter JAK-STAT Cascade Viral Process Cytokine-mediated Signaling Pathway Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)	Height ( 20881960 23456168) Psoriasis ( 19169254)
Protein-Protein Interactions		14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18	17 interactors: CREBBP CXCR4 EP300 FNTA GAA HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		3455	6773
HPRD ID		03850	02778
Ensembl ID		ENSG00000159110	ENSG00000170581
Uniprot IDs		P48551 Q9BUA0	P52630 R9QE65
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	2KA4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels	Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response Cellular Response To Organic Substance Response To Cytokine Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Response To Organic Substance Regulation Of Innate Immune Response Regulation Of Signal Transduction JAK-STAT Cascade Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Response To Stress Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Signaling Cell Communication Response To Virus Regulation Of Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Interferon-gamma-mediated Signaling Pathway Interaction With Symbiont Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Autophosphorylation Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cytokine Production Positive Regulation Of Gene Expression Regulation Of Tubulin Deacetylation Cellular Response To Stimulus Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Response To Interferon-gamma Histone Modification Response To Other Organism Transcription, DNA-templated Response To Biotic Stimulus
Tagcloud ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast
Tagcloud (Difference) ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast
Tagcloud (Intersection) ?