IFNAR2

Description		interferon alpha and beta receptor subunit 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex
	Molecular Function	Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Protein Kinase Binding Cytokine Binding Type I Interferon Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Response To Interferon-alpha Response To Interferon-beta Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus
Pathways
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin Ropeginterferon alfa-2b
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) COVID-19 ( 33949668) Crohn's disease ( 23128233) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Novel Interacting Genes		1 novel interacting genes: HLCS
Interacting Genes		15 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKAR2A PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		3455
HPRD ID		03850
Ensembl ID		ENSG00000159110
Uniprot IDs		P48551 Q9BUA0
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Cellular Response To Virus Cytokine-mediated Signaling Pathway Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Defense Response To Virus Response To Other Organism Cytokine Receptor Binding Response To External Biotic Stimulus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Response To Exogenous DsRNA Response To DsRNA Interleukin-10-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Adaptive Immune Response Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT B Cell Activation Involved In Immune Response T Cell Activation Involved In Immune Response B Cell Activation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Cellular Response To Interferon-beta Positive Regulation Of Protein Localization ISGF3 Complex Response To Interferon-beta Immune Response Lymphocyte Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Leukocyte Activation Involved In Immune Response Defense Response Regulation Of Protein Localization To Nucleus Cell Activation Involved In Immune Response Interleukin-23-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Signal Transduction Regulation Of Immune System Process Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Negative Regulation Of Immune Response Cytokine Activity
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