IFNAR2 and IFNB1

Number of citations of the paper that reports this interaction (PubMedID 10395669)
0

Data Source:
HPRD (in vivo)

		IFNAR2	IFNB1
Description		interferon alpha and beta receptor subunit 2	interferon beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Protein Kinase Binding Cytokine Binding Type I Interferon Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding Chloramphenicol O-acetyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Response To Interferon-alpha Response To Interferon-beta Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of Immune System Process Regulation Of Transcription By RNA Polymerase II Response To Stress Defense Response Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Innate Immune Response Leukocyte Activation Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Type I Interferon-mediated Signaling Pathway Neuron Cellular Homeostasis Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of Lewy Body Formation Antiviral Innate Immune Response Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin Ropeginterferon alfa-2b	Beta-D-Glucose
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) COVID-19 ( 33949668) Crohn's disease ( 23128233) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)	Axial length ( 24144296)
Interacting Genes		15 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKAR2A PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18	8 interacting genes: IFNAR1 IFNAR2 PEX19 S100A1 S100A4 S100A6 S100B S100P
Entrez ID		3455	3456
HPRD ID		03850	00972
Ensembl ID		ENSG00000159110	ENSG00000171855
Uniprot IDs		P48551 Q9BUA0	P01574
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	1AU1
Enriched GO Terms of Interacting Partners?		Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Cellular Response To Virus Cytokine-mediated Signaling Pathway Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Defense Response To Virus Response To Other Organism Cytokine Receptor Binding Response To External Biotic Stimulus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Response To Exogenous DsRNA Response To DsRNA Interleukin-10-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Adaptive Immune Response Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT B Cell Activation Involved In Immune Response T Cell Activation Involved In Immune Response B Cell Activation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Cellular Response To Interferon-beta Positive Regulation Of Protein Localization ISGF3 Complex Response To Interferon-beta Immune Response Lymphocyte Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Leukocyte Activation Involved In Immune Response Defense Response Regulation Of Protein Localization To Nucleus Cell Activation Involved In Immune Response Interleukin-23-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Signal Transduction Regulation Of Immune System Process Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Negative Regulation Of Immune Response Cytokine Activity	Calcium-dependent Protein Binding S100 Protein Binding Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Calcium Ion Binding RAGE Receptor Binding Response To Interferon-alpha Transition Metal Ion Binding Cellular Response To Interferon-beta Extracellular Region Response To Interferon-beta Cytokine Binding Protein Homodimerization Activity Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Identical Protein Binding Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT ATPase Binding Interferon Receptor Activity Positive Regulation Of Protein Localization To Nucleus Peroxisome Membrane Targeting Sequence Binding Ruffle Peroxisome Membrane Biogenesis Regulation Of Protein Localization To Nucleus Axonogenesis Protein Import Into Peroxisome Membrane Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Membrane Biogenesis Perinuclear Region Of Cytoplasm Negative Regulation Of Skeletal Muscle Cell Differentiation Receptor Complex Cellular Response To Interferon-alpha Protein Targeting To Peroxisome Protein Carrier Chaperone Positive Regulation Of Canonical NF-kappaB Signal Transduction Peroxisome Fission Monoatomic Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Respiration Tropomyosin Binding Neuron Projection Morphogenesis A Band Cell Projection Morphogenesis
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