IFNAR2 and STAT3

Number of citations of the paper that reports this interaction (PMID 12105218)
5

Data Source:
HPRD (in vivo)

		IFNAR2	STAT3
Gene Name		interferon (alpha, beta and omega) receptor 2	signal transducer and activator of transcription 3 (acute-phase response factor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane
	Molecular Function	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Import Into Nucleus Movement Of Cell Or Subcellular Component Acute-phase Response Signal Transduction JAK-STAT Cascade Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Somatic Stem Cell Maintenance Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Eating Behavior Response To Ethanol Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Astrocyte Differentiation Radial Glial Cell Differentiation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Cell Death Interleukin-6-mediated Signaling Pathway Negative Regulation Of Neuron Migration
Pathways			Signaling by PDGF Signalling by NGF Signaling by FGFR in disease Cellular Senescence Interleukin-6 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by SCF-KIT Signaling by Interleukins Transcriptional regulation of pluripotent stem cells Downstream signal transduction Signaling by FGFR1 mutants Signalling to STAT3 Signaling by FGFR mutants Signaling by FGFR1 fusion mutants POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Leptin Growth hormone receptor signaling
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)	Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088 20159113)
Protein-Protein Interactions		14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18	161 interactors: ADRB2 AMBP AR ARFIP2 ASXL1 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 CAPN1 CAPNS1 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBB2IP FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNB2L1 GNL3 GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HIC1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KPNA1 KPNA6 LAMB2 LCK LEP LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MET MORC4 MRPS31 MTOR MYOD1 NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 OGDHL PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PML PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RAC1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 SCAF11 SETD7 SIAH1 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 SSSCA1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TRIM28 TRIP10 TSHR TSLP ZFPM2 ZNF148 ZNF467
Entrez ID		3455	6774
HPRD ID		03850	00026
Ensembl ID		ENSG00000159110	ENSG00000168610
Uniprot IDs		P48551 Q9BUA0	K7ENL3 P40763
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels	Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Defense Response Response To Cytokine Regulation Of Signal Transduction Immune System Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Communication Signaling Positive Regulation Of Gene Expression Response To Stress Response To Stimulus Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Regulation Of Immune Response Immune Response Protein Autophosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Response To External Stimulus Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation
Tagcloud ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Difference) ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Intersection) ?