IFNAR2 and IFNA2

Number of citations of the paper that reports this interaction (PubMedID 11888273)
0

Data Source:
HPRD (in vitro)

		IFNAR2	IFNA2
Description		interferon alpha and beta receptor subunit 2	interferon alpha 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Protein Kinase Binding Cytokine Binding Type I Interferon Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Response To Interferon-alpha Response To Interferon-beta Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Defense Response Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways			Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin Ropeginterferon alfa-2b	Sifalimumab
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) COVID-19 ( 33949668) Crohn's disease ( 23128233) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)	Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		15 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKAR2A PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18	3 interacting genes: IFNAR1 IFNAR2 TIMMDC1
Entrez ID		3455	3440
HPRD ID		03850	00950
Ensembl ID		ENSG00000159110	ENSG00000188379
Uniprot IDs		P48551 Q9BUA0	P01563
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	1ITF 1RH2 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?		Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Cellular Response To Virus Cytokine-mediated Signaling Pathway Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Defense Response To Virus Response To Other Organism Cytokine Receptor Binding Response To External Biotic Stimulus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Response To Exogenous DsRNA Response To DsRNA Interleukin-10-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Adaptive Immune Response Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT B Cell Activation Involved In Immune Response T Cell Activation Involved In Immune Response B Cell Activation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Cellular Response To Interferon-beta Positive Regulation Of Protein Localization ISGF3 Complex Response To Interferon-beta Immune Response Lymphocyte Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Leukocyte Activation Involved In Immune Response Defense Response Regulation Of Protein Localization To Nucleus Cell Activation Involved In Immune Response Interleukin-23-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Signal Transduction Regulation Of Immune System Process Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Negative Regulation Of Immune Response Cytokine Activity	Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Response To Interferon-alpha Cellular Response To Interferon-beta Response To Interferon-beta Cytokine Binding Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Interferon Receptor Activity Receptor Complex Response To Virus Cellular Response To Interferon-alpha Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Cellular Respiration Response To Cytokine Response To Peptide Mitochondrial Respiratory Chain Complex I Assembly NADH Dehydrogenase Complex Assembly Regulation Of Cellular Respiration Regulation Of Protein Localization Response To Other Organism Mitochondrial Respiratory Chain Complex Assembly Response To External Biotic Stimulus
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