IFNAR2 and STAT1

Number of citations of the paper that reports this interaction (PMID 11301323)
14

Data Source:
HPRD (in vivo, in vitro)

		IFNAR2	STAT1
Gene Name		interferon (alpha, beta and omega) receptor 2	signal transducer and activator of transcription 1, 91kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite
	Molecular Function	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Negative Regulation Of Macrophage Fusion Cellular Response To Interferon-beta Response To Drug Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Renal Tubule Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways			Signaling by PDGF Signaling by FGFR in disease ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Signaling by SCF-KIT Downstream signal transduction Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18	103 interactors: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DOT1L DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 ERBB2 FADD FANCC FGFR3 FGFR4 FLT1 FOS FYN GFAP GNB2L1 GTF2I HADH HLA-B HSF1 HSP90AB1 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBC UBE2I VDR XPO1 ZNF467
Entrez ID		3455	6772
HPRD ID		03850	02777
Ensembl ID		ENSG00000159110	ENSG00000115415
Uniprot IDs		P48551 Q9BUA0	J3KPM9 P42224
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	1BF5 1YVL 2KA6
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels	Cellular Response To Organic Substance Response To Organic Substance Defense Response Innate Immune Response Response To Cytokine Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Signaling Response To Stress Regulation Of Immune System Process Cell Communication Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Protein Autophosphorylation Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Regulation Of Signaling Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Viral Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?