IFNAR2 and USP18

Number of citations of the paper that reports this interaction (PMID 16710296)
58

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		IFNAR2	USP18
Gene Name		interferon (alpha, beta and omega) receptor 2	ubiquitin specific peptidase 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytosol
	Molecular Function	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding ISG15-specific Protease Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Protein Deubiquitination Cytokine-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process
Pathways			Regulation of IFNA signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18	4 interactors: IFNAR2 ISG15 TRIM54 ZDHHC17
Entrez ID		3455	11274
HPRD ID		03850	06136
Ensembl ID		ENSG00000159110	ENSG00000184979
Uniprot IDs		P48551 Q9BUA0	Q53Y90 Q9UMW8
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels See more	Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Response To Virus ISG15-protein Conjugation Cytokine-mediated Signaling Pathway Signal Transduction Response To Interferon-alpha Signaling Lipoprotein Transport Positive Regulation Of Erythrocyte Differentiation Magnesium Ion Transport Cellular Response To Cytokine Stimulus Cell Communication Protein Palmitoylation Response To Cytokine Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Microtubule Depolymerization Regulation Of Erythrocyte Differentiation Cellular Response To Stimulus Innate Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Genome Replication Negative Regulation Of Microtubule Polymerization Or Depolymerization JAK-STAT Cascade See more
Tagcloud ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	appearance downregulating egress exploits g3bp1 granule granules hairpin hcv illustrate infectious infectivity interferon inverse machinery mxa opting rasgap sg sgs sh3 shrna tia tia1 tiar titers triggering triggers ways
Tagcloud (Difference) ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	appearance downregulating egress exploits g3bp1 granule granules hairpin hcv illustrate infectious infectivity interferon inverse machinery mxa opting rasgap sg sgs sh3 shrna tia tia1 tiar titers triggering triggers ways
Tagcloud (Intersection) ?