IFNAR2 and PPP1R3B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IFNAR2	PPP1R3B
Description		interferon alpha and beta receptor subunit 2	protein phosphatase 1 regulatory subunit 3B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex	Protein Phosphatase Type 1 Complex Glycogen Granule
	Molecular Function	Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Protein Kinase Binding Cytokine Binding Type I Interferon Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Enzyme Binding [phosphorylase] Phosphatase Activity Glycogen Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Response To Interferon-alpha Response To Interferon-beta Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glycogen Catabolic Process
Pathways
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin Ropeginterferon alfa-2b
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) COVID-19 ( 33949668) Crohn's disease ( 23128233) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)	Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Alcohol use disorder (consumption score) ( 30940813) Aluminium levels ( 26025379) Alzheimer's disease ( 22832961) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee or tea ( 33287642) Cholesterol, total ( 25961943 20686565 24097068) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Fibrinogen levels ( 28107422) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pregnancy) ( 23903356) Glycine levels ( 31070104) HDL cholesterol ( 20686565 21347282 23505323 23726366 25961943 24097068) HDL cholesterol levels ( 28334899) Joint mobility (Beighton score) ( 27182965) LDL cholesterol ( 20686565 20864672 25961943 24097068) LDL cholesterol levels ( 28334899) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver volume ( 34128465) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483 22916037) Myopia (pathological) ( 23049088) Neuroticism ( 29255261) Nose size ( 27182965) Number of sexual partners ( 30643258) Peak expiratory flow ( 30804560) Plasma lactate levels ( 26433129) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKAR2A PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18	7 interacting genes: IFNAR2 PLCE1 PPP1CA PPP1CB PRKAB2 PYGB PYGM
Entrez ID		3455	79660
HPRD ID		03850	17894
Ensembl ID		ENSG00000159110	ENSG00000173281
Uniprot IDs		P48551 Q9BUA0	Q86XI6
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	2EEF 5ZT0
Enriched GO Terms of Interacting Partners?		Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Cellular Response To Virus Cytokine-mediated Signaling Pathway Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Defense Response To Virus Response To Other Organism Cytokine Receptor Binding Response To External Biotic Stimulus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Response To Exogenous DsRNA Response To DsRNA Interleukin-10-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Adaptive Immune Response Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT B Cell Activation Involved In Immune Response T Cell Activation Involved In Immune Response B Cell Activation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Cellular Response To Interferon-beta Positive Regulation Of Protein Localization ISGF3 Complex Response To Interferon-beta Immune Response Lymphocyte Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Leukocyte Activation Involved In Immune Response Defense Response Regulation Of Protein Localization To Nucleus Cell Activation Involved In Immune Response Interleukin-23-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Signal Transduction Regulation Of Immune System Process Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Negative Regulation Of Immune Response Cytokine Activity	Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity PTW/PP1 Phosphatase Complex Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Glycogen Catabolic Process Entrainment Of Circadian Clock By Photoperiod Polysaccharide Catabolic Process Photoperiodism Entrainment Of Circadian Clock Pyridoxal Phosphate Binding Circadian Regulation Of Gene Expression Phosphatase Activity Myosin-light-chain-phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Kinase Binding Type I Interferon Receptor Activity Type I Interferon Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Circadian Rhythm Carbohydrate Catabolic Process JAK Pathway Signal Transduction Adaptor Activity Dephosphorylation Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Phosphoprotein Phosphatase Activity Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Myosin Phosphatase Activity Diacylglycerol Biosynthetic Process Chromosome, Telomeric Region Glycogen Granule AMP-activated Protein Kinase Activity Glycosyltransferase Activity RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Rhythmic Process Nucleotide-activated Protein Kinase Complex Extracellular Exosome Phospholipase C Activity Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex
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