IFNAR2 and PPP1R3B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IFNAR2	PPP1R3B
Gene Name		interferon (alpha, beta and omega) receptor 2	protein phosphatase 1, regulatory subunit 3B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Protein Phosphatase Type 1 Complex Glycogen Granule Intracellular Membrane-bounded Organelle
	Molecular Function	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding	Phosphoprotein Phosphatase Activity Protein Phosphatase Regulator Activity Enzyme Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Dephosphorylation Regulation Of Catalytic Activity
Pathways
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)	Alzheimer's disease ( 22832961) C-reactive protein ( 21300955) Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 23726366 23505323 20686565) LDL cholesterol ( 20864672 20686565) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolite levels ( 22916037) Myopia (pathological) ( 23049088)
Protein-Protein Interactions		14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18	2 interactors: IFNAR2 PPP1CA
Entrez ID		3455	79660
HPRD ID		03850	17894
Ensembl ID		ENSG00000159110	ENSG00000173281
Uniprot IDs		P48551 Q9BUA0	Q86XI6
PDB IDs		1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4	2EEF
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels	Regulation Of Glycogen Catabolic Process Response To Interferon-alpha Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Glycogen Metabolic Process Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To External Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Organic Substance Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Neutral Lipid Metabolic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Type I Interferon Response To Organic Substance Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Signal Transduction Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Carbohydrate Metabolic Process Morphogenesis Of A Branching Epithelium Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	05e abca7 apoe attributable bin1 cd2ap cd33 clu cr1 epha1 gwas gwass illumina imputed loci meta ms4a4 ms4a6e nominal omni1 picalm pittsburg pittsburgh quad rs3848140 snp snps suggestive top
Tagcloud (Difference) ?		aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1	05e abca7 apoe attributable bin1 cd2ap cd33 clu cr1 epha1 gwas gwass illumina imputed loci meta ms4a4 ms4a6e nominal omni1 picalm pittsburg pittsburgh quad rs3848140 snp snps suggestive top
Tagcloud (Intersection) ?