IFIT3 and ECSIT

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		IFIT3	ECSIT
Gene Name		interferon-induced protein with tetratricopeptide repeats 3	ECSIT signalling integrator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Negative Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: A2M APOE AQPEP CCDC67 CDC37 CYP2C8 ECSIT FANCA HAUS1 IFIT1 IFIT2 IFIT5 LONP1 MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM3	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		3437	51295
HPRD ID		05228	12225
Ensembl ID		ENSG00000119917	ENSG00000130159
Uniprot IDs		O14879 Q5T765	K7EMM0 Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Binding Response To Stress Negative Regulation Of Binding Positive Regulation Of Viral Genome Replication Regulation Of Protein Binding Defense Response To Virus Regulation Of Binding Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Response To Virus Response To External Stimulus Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Component Assembly Regulation Of Oxidoreductase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Immune Response Innate Immune Response Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Response To Stimulus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Microtubule Organizing Center Organization Multi-ciliated Epithelial Cell Differentiation Response To Type I Interferon Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Intracellular Transport Of Viral Protein In Host Cell Regulation Of Presynaptic Membrane Organization Organelle Organization Negative Regulation Of Dendritic Spine Development	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?