IFIT3 and IFIT1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (two hybrid)

		IFIT3	IFIT1
Gene Name		interferon-induced protein with tetratricopeptide repeats 3	interferon-induced protein with tetratricopeptide repeats 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway	Response To Virus Intracellular Transport Of Viral Protein In Host Cell Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Negative Regulation Of Defense Response To Virus By Host Negative Regulation Of Helicase Activity Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: A2M APOE AQPEP CCDC67 CDC37 CYP2C8 ECSIT FANCA HAUS1 IFIT1 IFIT2 IFIT5 LONP1 MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM3	4 interactors: EIF3E IFIT2 IFIT3 IFIT5
Entrez ID		3437	3434
HPRD ID		05228	00983
Ensembl ID		ENSG00000119917
Uniprot IDs		O14879 Q5T765	D3DR31 P09914
PDB IDs			4HOU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Binding Response To Stress Negative Regulation Of Binding Positive Regulation Of Viral Genome Replication Regulation Of Protein Binding Defense Response To Virus Regulation Of Binding Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Response To Virus Response To External Stimulus Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Component Assembly Regulation Of Oxidoreductase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Immune Response Innate Immune Response Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Response To Stimulus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Microtubule Organizing Center Organization Multi-ciliated Epithelial Cell Differentiation Response To Type I Interferon Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Intracellular Transport Of Viral Protein In Host Cell Regulation Of Presynaptic Membrane Organization Organelle Organization Negative Regulation Of Dendritic Spine Development	Cellular Response To Interferon-alpha Defense Response To Virus Response To Interferon-alpha Response To Virus Response To Other Organism Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Biotic Stimulus Response To Type I Interferon Innate Immune Response Immune Response Defense Response Response To External Stimulus Cytokine-mediated Signaling Pathway Immune System Process Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Cellular Response To Cytokine Stimulus Response To Cytokine Negative Regulation Of Protein Binding Response To Stress
Tagcloud ?		adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma ifi27 irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1 trail
Tagcloud (Difference) ?		adenovirus apobec3a ddx58 exact expand hiv ifi44l ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 viperin vpr	activates becomes canonical confers constitutive constitutively dissociates egfr epidermal erk exclusive glioblastoma irf3 leading mechanistically modes mutually oncogenic oscillates overexpressed regular shc signalling signals switch switches tbk1
Tagcloud (Intersection) ?		ifi27 ifit1 trail