IFIT3 and FANCA

Number of citations of the paper that reports this interaction (PubMedID 14499622)
0

Data Source:
BioGRID (two hybrid)

		IFIT3	FANCA
Description		interferon induced protein with tetratricopeptide repeats 3	FA complementation group A
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Apoptotic Process Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway
Pathways		Interferon alpha/beta signaling	Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases			Fanconi anemia
GWAS		Hormone measurements ( 30576415)	Brain morphology (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 30054594 31959993) Low tan response ( 29739929) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		21 interacting genes: A2M ANXA1 APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3	47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		3437	2175
HPRD ID		05228	06186
Ensembl ID		ENSG00000119917	ENSG00000187741
Uniprot IDs		A0A7P0T7D6 O14879 Q5T765	O15360 Q0VAP4
PDB IDs		6C6K	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Translation RNA Sequestering Activity Muscle Thin Filament Tropomyosin Regulation Of Viral Process Response To Stress Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Actin Filament Amyloid Precursor Protein Metabolic Process Defense Response To Virus Regulation Of Viral Life Cycle Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Response To Virus Positive Regulation Of Viral Genome Replication Positive Regulation Of Heart Rate By Epinephrine Oxidation-dependent Protein Catabolic Process	Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus
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