IFIT3 and IFIT2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		IFIT3	IFIT2
Gene Name		interferon-induced protein with tetratricopeptide repeats 3	interferon-induced protein with tetratricopeptide repeats 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway	Apoptotic Mitochondrial Changes Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Binding Cellular Response To Interferon-alpha Positive Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: A2M APOE AQPEP CCDC67 CDC37 CYP2C8 ECSIT FANCA HAUS1 IFIT1 IFIT2 IFIT5 LONP1 MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM3	3 interactors: IFIT1 IFIT3 NUTM1
Entrez ID		3437	3433
HPRD ID		05228	00913
Ensembl ID		ENSG00000119917	ENSG00000119922
Uniprot IDs		O14879 Q5T765	P09913 Q05DN2
PDB IDs			4G1T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Binding Response To Stress Negative Regulation Of Binding Positive Regulation Of Viral Genome Replication Regulation Of Protein Binding Defense Response To Virus Regulation Of Binding Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Response To Virus Response To External Stimulus Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Component Assembly Regulation Of Oxidoreductase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Immune Response Innate Immune Response Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Response To Stimulus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Microtubule Organizing Center Organization Multi-ciliated Epithelial Cell Differentiation Response To Type I Interferon Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Intracellular Transport Of Viral Protein In Host Cell Regulation Of Presynaptic Membrane Organization Organelle Organization Negative Regulation Of Dendritic Spine Development	Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response To Virus Response To Virus Negative Regulation Of Helicase Activity Cytokine-mediated Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Cellular Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Interferon-alpha Negative Regulation Of Defense Response To Virus By Host Response To Cytokine Response To Other Organism Response To Biotic Stimulus Innate Immune Response Response To Interferon-alpha Positive Regulation Of Viral Genome Replication Negative Regulation Of Defense Response To Virus Intracellular Transport Of Virus Regulation Of Defense Response To Virus By Host Immune Response Cellular Response To DsRNA Defense Response Negative Regulation Of Viral Genome Replication Response To Exogenous DsRNA Negative Regulation Of Protein Binding Regulation Of Viral Genome Replication Response To External Stimulus Positive Regulation Of Viral Process Response To DsRNA Negative Regulation Of Viral Process Cellular Response To Organic Substance Regulation Of Defense Response To Virus Negative Regulation Of Binding Immune System Process Interaction With Host Response To Organic Substance Regulation Of Protein Binding Regulation Of Viral Process Viral Life Cycle Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Binding Negative Regulation Of Immune System Process
Tagcloud ?		adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr