KRT27 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT27	ARHGEF6
Description		keratin 27	Rac/Cdc42 guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cell Projection
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Hair Follicle Morphogenesis Intermediate Filament Organization	Apoptotic Process JNK Cascade Lamellipodium Assembly
Pathways		Keratinization Formation of the cornified envelope	NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Asthma ( 31959851)	Autism spectrum disorder ( 34069769) Breast cancer ( 29059683)
Interacting Genes		139 interacting genes: AARD ABI2 AMOT ARFIP1 ARHGEF6 ATP6V1D BCAS2 BEX2 BFSP2 C19orf44 C1orf216 C21orf58 CCBE1 CCDC138 CCDC146 CCDC185 CCDC187 CCDC22 CCDC68 CCHCR1 CCNC CEP95 CFAP58 COX5B DPPA3 DTNB DUSP26 EXOC3L1 EXOSC5 FAM107A FAM110A FMNL2 GADD45GIP1 GFAP GNG13 GOLGA1 GPS2 GSTK1 HAPLN2 HDAC4 HGS HOXB9 HSPBP1 ICA1L IGF1R INSR INSRR JOSD1 KANK2 KIAA1217 KLHL38 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LKAAEAR1 LMNTD2 MATR3 MBD3L2 MID2 MORN4 MOS MTMR9 NDC80 NDUFAF3 NTAQ1 NUP54 NUP58 ODAD3 OIP5 PBX3 PCDHB14 PNN POLL PPP1R18 PRPH PSMC5 RASAL3 RBM41 RCOR3 RNF39 RTP5 RUNX1T1 SCNM1 SDHAF1 SEMA4C SLC22A5 SLIRP SMARCC2 SMARCD1 SMARCE1 SSC5D SSX3 SUFU SUOX TBRG4 TEAD4 TEDC2 TEX28 THAP7 TNNT1 TRAF3IP3 TRIML2 TSKS TTC23 TXLNB TXN2 USHBP1 USP2 VPS37C WASHC3 XRCC4 ZC3H14 ZFYVE26 ZNF3 ZNF580 ZNF581 ZNF669 ZNF80	36 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		342574	9459
HPRD ID		17244	02226
Ensembl ID		ENSG00000171446	ENSG00000129675
Uniprot IDs		Q7Z3Y8	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Keratinization Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Protein Binding Organelle Organization Insulin Receptor Activity Structural Constituent Of Cytoskeleton Insulin Receptor Complex Intermediate Filament Cytoskeleton Structural Molecule Activity Insulin Receptor Substrate Binding Epidermis Development Brahma Complex NpBAF Complex RSC-type Complex NBAF Complex Phosphatidylinositol 3-kinase Binding Nucleosome Disassembly Insulin Binding	Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Dendritic Spine Development I-SMAD Binding Cellular Response To Growth Factor Stimulus Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Ephrin Receptor Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Stress Fiber Assembly Co-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Protein Kinase Binding Homomeric SMAD Protein Complex Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Nucleation Protein Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Actin Filament-based Process Response To Transforming Growth Factor Beta Immune System Process Regulation Of Cartilage Development Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament Organization Response To Cholesterol Roof Of Mouth Development Response To Stress Positive Regulation Of Cell Motility Regulation Of Organelle Organization Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?