KRT27 and CCDC22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT27	CCDC22
Description		keratin 27	CCC complex scaffolding subunit CCDC22
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cytoskeleton
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Cullin Family Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Hair Follicle Morphogenesis Intermediate Filament Organization	Intracellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Protein Transport Endocytic Recycling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Keratinization Formation of the cornified envelope	Neddylation
Drugs
Diseases
GWAS		Asthma ( 31959851)	Vitiligo ( 27723757)
Interacting Genes		139 interacting genes: AARD ABI2 AMOT ARFIP1 ARHGEF6 ATP6V1D BCAS2 BEX2 BFSP2 C19orf44 C1orf216 C21orf58 CCBE1 CCDC138 CCDC146 CCDC185 CCDC187 CCDC22 CCDC68 CCHCR1 CCNC CEP95 CFAP58 COX5B DPPA3 DTNB DUSP26 EXOC3L1 EXOSC5 FAM107A FAM110A FMNL2 GADD45GIP1 GFAP GNG13 GOLGA1 GPS2 GSTK1 HAPLN2 HDAC4 HGS HOXB9 HSPBP1 ICA1L IGF1R INSR INSRR JOSD1 KANK2 KIAA1217 KLHL38 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LKAAEAR1 LMNTD2 MATR3 MBD3L2 MID2 MORN4 MOS MTMR9 NDC80 NDUFAF3 NTAQ1 NUP54 NUP58 ODAD3 OIP5 PBX3 PCDHB14 PNN POLL PPP1R18 PRPH PSMC5 RASAL3 RBM41 RCOR3 RNF39 RTP5 RUNX1T1 SCNM1 SDHAF1 SEMA4C SLC22A5 SLIRP SMARCC2 SMARCD1 SMARCE1 SSC5D SSX3 SUFU SUOX TBRG4 TEAD4 TEDC2 TEX28 THAP7 TNNT1 TRAF3IP3 TRIML2 TSKS TTC23 TXLNB TXN2 USHBP1 USP2 VPS37C WASHC3 XRCC4 ZC3H14 ZFYVE26 ZNF3 ZNF580 ZNF581 ZNF669 ZNF80	8 interacting genes: ACTG1 ARSA BLOC1S6 CPNE1 CPNE4 KRT27 OIP5 USHBP1
Entrez ID		342574	28952
HPRD ID		17244	06594
Ensembl ID		ENSG00000171446	ENSG00000101997
Uniprot IDs		Q7Z3Y8	O60826
PDB IDs			8F2U 8P0V 8P0W 8P0X
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Keratinization Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Protein Binding Organelle Organization Insulin Receptor Activity Structural Constituent Of Cytoskeleton Insulin Receptor Complex Intermediate Filament Cytoskeleton Structural Molecule Activity Insulin Receptor Substrate Binding Epidermis Development Brahma Complex NpBAF Complex RSC-type Complex NBAF Complex Phosphatidylinositol 3-kinase Binding Nucleosome Disassembly Insulin Binding	Filamentous Actin Basal Body Patch Cerebroside-sulfatase Activity Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle
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