KRT27 and DUSP26

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT27	DUSP26
Description		keratin 27	dual specificity phosphatase 26
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	P53 Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Hair Follicle Morphogenesis Intermediate Filament Organization	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31959851)	Body mass index ( 25673413 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Morning person ( 30696823) Reading disability ( 32108986) Self-reported risk-taking behaviour ( 30271922)
Interacting Genes		139 interacting genes: AARD ABI2 AMOT ARFIP1 ARHGEF6 ATP6V1D BCAS2 BEX2 BFSP2 C19orf44 C1orf216 C21orf58 CCBE1 CCDC138 CCDC146 CCDC185 CCDC187 CCDC22 CCDC68 CCHCR1 CCNC CEP95 CFAP58 COX5B DPPA3 DTNB DUSP26 EXOC3L1 EXOSC5 FAM107A FAM110A FMNL2 GADD45GIP1 GFAP GNG13 GOLGA1 GPS2 GSTK1 HAPLN2 HDAC4 HGS HOXB9 HSPBP1 ICA1L IGF1R INSR INSRR JOSD1 KANK2 KIAA1217 KLHL38 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LKAAEAR1 LMNTD2 MATR3 MBD3L2 MID2 MORN4 MOS MTMR9 NDC80 NDUFAF3 NTAQ1 NUP54 NUP58 ODAD3 OIP5 PBX3 PCDHB14 PNN POLL PPP1R18 PRPH PSMC5 RASAL3 RBM41 RCOR3 RNF39 RTP5 RUNX1T1 SCNM1 SDHAF1 SEMA4C SLC22A5 SLIRP SMARCC2 SMARCD1 SMARCE1 SSC5D SSX3 SUFU SUOX TBRG4 TEAD4 TEDC2 TEX28 THAP7 TNNT1 TRAF3IP3 TRIML2 TSKS TTC23 TXLNB TXN2 USHBP1 USP2 VPS37C WASHC3 XRCC4 ZC3H14 ZFYVE26 ZNF3 ZNF580 ZNF581 ZNF669 ZNF80	11 interacting genes: CALCOCO2 CARD10 EPHA2 EPHA7 GOLGA6L9 GRIPAP1 HSF4 IGF1R KRT27 PTK7 RET
Entrez ID		342574	78986
HPRD ID		17244	14421
Ensembl ID		ENSG00000171446	ENSG00000133878
Uniprot IDs		Q7Z3Y8	Q9BV47
PDB IDs			2E0T 4B04 4HRF 5GTJ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Keratinization Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Protein Binding Organelle Organization Insulin Receptor Activity Structural Constituent Of Cytoskeleton Insulin Receptor Complex Intermediate Filament Cytoskeleton Structural Molecule Activity Insulin Receptor Substrate Binding Epidermis Development Brahma Complex NpBAF Complex RSC-type Complex NBAF Complex Phosphatidylinositol 3-kinase Binding Nucleosome Disassembly Insulin Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Tissue Morphogenesis Protein Kinase Activity Axon Guidance Receptor Activity Ephrin Receptor Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Axon Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Positive Regulation Of Protein-containing Complex Disassembly Neuron Projection Guidance Axon Guidance Growth Factor Binding Positive Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Notochord Cell Development Kinase Activity Ephrin Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Projection Organization Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid ATP Binding Anatomical Structure Morphogenesis Axial Mesoderm Formation Neuronal Cell Body Posterior Midgut Development Negative Regulation Of Receptor Clustering Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Negative Regulation Of Lymphangiogenesis Notochord Formation Plasma Membrane Bounded Cell Projection Organization Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Activity Response To Retinoic Acid Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Regulation Of Protein Localization To Plasma Membrane Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Insulin Receptor Complex
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