IDH1 and FILNC1

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		IDH1	FILNC1
Description		isocitrate dehydrogenase (NADP(+)) 1	FOXO induced long non-coding RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding NADP Binding NAD Binding
	Biological Process	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways		Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import NFE2L2 regulating TCA cycle genes
Drugs		Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib Olutasidenib
Diseases
GWAS		Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)	Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		19 interacting genes: AGGF1 CALM1 CDK1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 FILNC1 LAX1 LINC01554 NUP62 PEX5 PLK1 PRDM14 SUMO4 TMOD4 UBL7 ZHX1	88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8
Entrez ID		3417	100132735
HPRD ID		00984
Ensembl ID		ENSG00000138413	ENSG00000231426
Uniprot IDs		A0A024R3Y6 O75874
PDB IDs		1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0 7PJM 7PJN 8BAY 8HB9 8T7D 8T7N 8T7O 8VH9 8VHA 8VHB 8VHC 8VHD 8VHE
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Centrosome Separation Regulation Of Cytokinesis Nuclear Membrane Disassembly Microtubule Organizing Center Organization Membrane Disassembly Protein Localization To Site Of Double-strand Break Mitotic Cell Cycle Phase Transition Regulation Of Cell Division Spindle Pole Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Pronuclear Fusion Cardiac Muscle Cell Development Chromosome Condensation Cardiac Cell Development Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Organization SH2 Domain Binding Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Methyltransferase Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Spindle Negative Regulation Of Apoptotic Process Mitotic DNA-templated DNA Replication Post-translational Protein Modification Nuclear Membrane Organization Cellular Response To Oxidative Stress Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Mitotic G2/M Transition Checkpoint Cyclin A2-CDK1 Complex Hsp70 Protein Binding Negative Regulation Of DNA-templated Transcription Atrial Cardiac Muscle Cell Development Negative Regulation Of RNA Biosynthetic Process Synaptonemal Complex Disassembly Golgi Inheritance Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Programmed Cell Death Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Chemical Stress	RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation
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