IDH1 and ZHX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IDH1	ZHX1
Gene Name		isocitrate dehydrogenase 1 (NADP+), soluble	zinc fingers and homeoboxes 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Receptor Binding Protein Homodimerization Activity NADP Binding NAD Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Response To Steroid Hormone	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		Metabolism of lipids and lipoproteins NADPH regeneration Peroxisomal lipid metabolism Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Drugs		Isocitric Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PEX5 SUMO4 ZHX1	50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX
Entrez ID		3417	11244
HPRD ID		00984	10379
Ensembl ID		ENSG00000138413	ENSG00000165156
Uniprot IDs		O75874 Q6FHQ6	Q9UKY1
PDB IDs		1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06	2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Protein Sumoylation Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Positive Regulation Of Multicellular Organism Growth Intracellular Protein Transmembrane Transport Mitochondrial Membrane Organization Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		dehydrogenase extension favorable glioblastoma glioblastomas histologically influenced isocitrate karnofsky kfs log methylation methylguanine methyltransferase mgmt mutation nevertheless o6 os pfs predictors prognostic promoter rank regard resection retrospectively stratify tp53	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Difference) ?		dehydrogenase extension favorable glioblastoma glioblastomas histologically influenced isocitrate karnofsky kfs log methylation methylguanine methyltransferase mgmt mutation nevertheless o6 os pfs predictors prognostic promoter rank regard resection retrospectively stratify tp53	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Intersection) ?