IDH1

Gene Name		isocitrate dehydrogenase 1 (NADP+), soluble
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Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Receptor Binding Protein Homodimerization Activity NADP Binding NAD Binding
	Biological Process	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Response To Steroid Hormone
Pathways		Metabolism of lipids and lipoproteins NADPH regeneration Peroxisomal lipid metabolism Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Drugs		Isocitric Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS
Protein-protein Interactions		3 interactors: PEX5 SUMO4 ZHX1
Entrez ID		3417
HPRD ID		00984
Ensembl ID		ENSG00000138413
Uniprot IDs		O75874 Q6FHQ6
PDB IDs		1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Protein Sumoylation Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Positive Regulation Of Multicellular Organism Growth Intracellular Protein Transmembrane Transport Mitochondrial Membrane Organization Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process
Tagcloud ?		dehydrogenase extension favorable glioblastoma glioblastomas histologically influenced isocitrate karnofsky kfs log methylation methylguanine methyltransferase mgmt mutation nevertheless o6 os pfs predictors prognostic promoter rank regard resection retrospectively stratify tp53