IDH1 and SUMO4

Number of citations of the paper that reports this interaction (PMID 16236267)
15

Data Source:
HPRD (in vivo)

		IDH1	SUMO4
Gene Name		isocitrate dehydrogenase 1 (NADP+), soluble	small ubiquitin-like modifier 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Receptor Binding Protein Homodimerization Activity NADP Binding NAD Binding
	Biological Process	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Response To Steroid Hormone	Protein Sumoylation
Pathways		Metabolism of lipids and lipoproteins NADPH regeneration Peroxisomal lipid metabolism Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Drugs		Isocitric Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PEX5 SUMO4 ZHX1	75 interactors: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GNB2L1 GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		3417	387082
HPRD ID		00984	10584
Ensembl ID		ENSG00000138413	ENSG00000177688
Uniprot IDs		O75874 Q6FHQ6	Q6EEV6
PDB IDs		1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Protein Sumoylation Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Positive Regulation Of Multicellular Organism Growth Intracellular Protein Transmembrane Transport Mitochondrial Membrane Organization Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process	Protein Folding Regulation Of Cell Death Regulation Of Apoptotic Process Cellular Metabolic Process Response To Unfolded Protein Response To Stress Negative Regulation Of Cell Death 'de Novo' Protein Folding Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toxin Transport Response To Organic Substance Nitrogen Compound Metabolic Process 'de Novo' Posttranslational Protein Folding Metabolic Process Cellular Response To Stress Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Endoplasmic Reticulum Stress Generation Of Precursor Metabolites And Energy Regulation Of Cellular Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Process Response To Reactive Oxygen Species Small Molecule Metabolic Process Organic Acid Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Protein Metabolic Process Carboxylic Acid Metabolic Process Protein Refolding Endoplasmic Reticulum Unfolded Protein Response Ribonucleoside Monophosphate Biosynthetic Process Carbohydrate Biosynthetic Process Cellular Response To Organic Substance MRNA Metabolic Process Cellular Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Nucleoside Monophosphate Biosynthetic Process Gluconeogenesis Monocarboxylic Acid Metabolic Process ER-nucleus Signaling Pathway Catabolic Process Ribose Phosphate Biosynthetic Process Apoptotic Process Biosynthetic Process Cellular Response To Topologically Incorrect Protein
Tagcloud ?		dehydrogenase extension favorable glioblastoma glioblastomas histologically influenced isocitrate karnofsky kfs log methylation methylguanine methyltransferase mgmt mutation nevertheless o6 os pfs predictors prognostic promoter rank regard resection retrospectively stratify tp53	accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2
Tagcloud (Difference) ?		dehydrogenase extension favorable glioblastoma glioblastomas histologically influenced isocitrate karnofsky kfs log methylation methylguanine methyltransferase mgmt mutation nevertheless o6 os pfs predictors prognostic promoter rank regard resection retrospectively stratify tp53	accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2
Tagcloud (Intersection) ?