IDH1 and FIGNL1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		IDH1	FIGNL1
Description		isocitrate dehydrogenase (NADP(+)) 1	fidgetin like 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding NADP Binding NAD Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import NFE2L2 regulating TCA cycle genes	Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination
Drugs		Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib Olutasidenib
Diseases
GWAS		Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)
Interacting Genes		19 interacting genes: AGGF1 CALM1 CDK1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 FILNC1 LAX1 LINC01554 NUP62 PEX5 PLK1 PRDM14 SUMO4 TMOD4 UBL7 ZHX1	7 interacting genes: DMC1 FIRRM GCC1 IDH1 ITGB1BP1 KDM1A SPIDR
Entrez ID		3417	63979
HPRD ID		00984	10958
Ensembl ID		ENSG00000138413	ENSG00000132436
Uniprot IDs		A0A024R3Y6 O75874	B3KNH6 Q6PIW4
PDB IDs		1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0 7PJM 7PJN 8BAY 8HB9 8T7D 8T7N 8T7O 8VH9 8VHA 8VHB 8VHC 8VHD 8VHE	3D8B 8R64
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Centrosome Separation Regulation Of Cytokinesis Nuclear Membrane Disassembly Microtubule Organizing Center Organization Membrane Disassembly Protein Localization To Site Of Double-strand Break Mitotic Cell Cycle Phase Transition Regulation Of Cell Division Spindle Pole Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Pronuclear Fusion Cardiac Muscle Cell Development Chromosome Condensation Cardiac Cell Development Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Organization SH2 Domain Binding Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Methyltransferase Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Spindle Negative Regulation Of Apoptotic Process Mitotic DNA-templated DNA Replication Post-translational Protein Modification Nuclear Membrane Organization Cellular Response To Oxidative Stress Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Mitotic G2/M Transition Checkpoint Cyclin A2-CDK1 Complex Hsp70 Protein Binding Negative Regulation Of DNA-templated Transcription Atrial Cardiac Muscle Cell Development Negative Regulation Of RNA Biosynthetic Process Synaptonemal Complex Disassembly Golgi Inheritance Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Programmed Cell Death Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Chemical Stress	Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Glyoxylate Cycle Isocitrate Metabolic Process Isocitrate Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Recombinational Repair DNA Strand Invasion DNA Metabolic Process DNA Recombinase Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Strand Exchange Activity Chromosome Catalytic Activity, Acting On DNA Chromosome, Telomeric Region Cell Maturation Regulation Of DNA Recombination Response To Fungicide MRF Binding Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Camptothecin Regulation Of Phospholipid Catabolic Process Glyoxylate Metabolic Process Activation Of Protein Kinase B Activity Developmental Maturation DNA Damage Response Histone H3K4 Demethylase Activity Regulation Of Establishment Of Protein Localization To Chromosome Golgi Trans Cisterna Double-strand Break Repair Regulation Of DNA Repair Regulation Of Protein Kinase Activity DNA Recombination Double-strand Break Repair Involved In Meiotic Recombination Histone H3K9 Demethylase Activity Integrin Activation Regulation Of Kinase Activity
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