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HGS and EXOC8
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
HGS
EXOC8
Gene Name
hepatocyte growth factor-regulated tyrosine kinase substrate
exocyst complex component 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endosome
Early Endosome
Cytosol
Secretory Granule
Early Endosome Membrane
Multivesicular Body Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Exocyst
Cytoplasm
Late Endosome
Cytosol
Plasma Membrane
Membrane
Growth Cone
Molecular Function
Protein Binding
Protein Domain Specific Binding
Metal Ion Binding
Protein Binding
Ral GTPase Binding
Biological Process
Protein Targeting To Lysosome
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell Proliferation
Endosome To Lysosome Transport
Membrane Invagination
Positive Regulation Of Gene Expression
Endosomal Transport
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Negative Regulation Of JAK-STAT Cascade
Membrane Organization
Protein Localization To Membrane
Positive Regulation Of Exosomal Secretion
Exocyst Assembly
Organelle Organization
Endosome Organization
Protein Transport
Extracellular Matrix Disassembly
Cellular Protein Metabolic Process
Exocyst Localization
Membrane Organization
Pathways
Signaling by EGFR
EGFR downregulation
Endosomal Sorting Complex Required For Transport (ESCRT)
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Peptide hormone metabolism
Cargo trafficking to the periciliary membrane
Organelle biogenesis and maintenance
Translocation of GLUT4 to the plasma membrane
VxPx cargo-targeting to cilium
Assembly of the primary cilium
Insulin processing
Drugs
Diseases
GWAS
Eye color traits (
20463881
)
Protein-Protein Interactions
138 interactors:
ABI2
ACLY
AHCYL1
APC
APLP2
APP
ARFIP2
ARL6IP1
ATP1A1
ATP2A2
ATXN1L
BCAS2
BEGAIN
BRINP3
BSG
CASK
CBS
CCDC103
CCDC114
CCDC33
CEP55
CEP57L1
CLTC
CRMP1
CSTF2
CSTF2T
CTTNBP2NL
DAZAP2
DCTN2
DECR1
DGCR6
DLG4
EGFR
EHMT2
EPS15
ESRRG
EXOC7
EXOC8
GFAP
GFI1B
GGA2
GKAP1
HAP1
HNRNPDL
HSPA8
IL2RB
IL4R
ILKAP
ING5
INTS4
JAKMIP2
KRT15
KRT18
KRT19
KRT31
KRT38
KRT40
KRT6A
LDOC1
LINC00265
LITAF
LURAP1
LYST
MAGEB4
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED7
MEST
MET
MIF4GD
MKNK1
MRFAP1L1
MTHFD1L
NDC80
NEDD4
NEDD4L
NF2
NMI
NPAS2
NUP54
OSBPL5
P4HA3
PAK1
PEF1
PELP1
PFKM
PIK3R1
PITX1
PLD3
POGZ
PPP1R16A
PPP1R7
PTCD3
RHOBTB3
RPS3A
RSU1
SCAMP3
SCRN1
SF3B3
SMAD2
SMAD3
SMAD5
SNAP25
SNX1
SNX5
SNX7
STAM
STAM2
STXBP1
SUMO1
SUN2
TADA2A
TIMMDC1
TJP2
TMCC2
TOM1L1
TRAK1
TRAP1
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN4
USHBP1
VMP1
VPS37A
VPS37C
VPS37D
ZNF302
20 interactors:
BLOC1S6
CCDC85B
CEP57L1
EFHC2
EXOC2
HGS
IKZF3
KRT15
KRT18
KRT19
KRT20
KRT31
LNX1
MBIP
PCM1
RAB3IL1
RALA
TADA2A
ULK1
USHBP1
Entrez ID
9146
149371
HPRD ID
05085
09943
Ensembl ID
ENSG00000185359
ENSG00000116903
Uniprot IDs
O14964
Q8IYI6
PDB IDs
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
?
Establishment Of Localization In Cell
Cellular Localization
Viral Protein Processing
Protein Localization
Intracellular Transport
Membrane Organization
Endosomal Transport
Establishment Of Protein Localization
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Protein Transport
Regulation Of ERBB Signaling Pathway
Virion Assembly
Intracellular Transport Of Virus
Viral Process
Cellular Protein Localization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Vesicle-mediated Transport
Viral Life Cycle
Cell Cycle Process
Organelle Organization
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Transport
Post-Golgi Vesicle-mediated Transport
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Metabolic Process
Gene Expression
Cell Cycle
Vesicle Organization
Secretion By Cell
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
ERBB Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Intracellular Protein Transport
Transcription Initiation From RNA Polymerase II Promoter
Cellular Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Posttranscriptional Regulation Of Gene Expression
Secretion
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
JNK Cascade
Response To Organic Substance
Organelle Organization
Protein Localization
Post-Golgi Vesicle-mediated Transport
Cytoskeleton Organization
Golgi To Plasma Membrane Transport
Membrane Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Microtubule Anchoring
Histone H3 Acetylation
Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway
Golgi To Plasma Membrane CFTR Protein Transport
Golgi Vesicle Transport
Cellular Localization
Cytoplasmic Transport
Radial Glia Guided Migration Of Cerebellar Granule Cell
Exocytosis
Establishment Of Localization In Cell
Membrane Raft Localization
Protein Transport
Histone Acetylation
Vesicle-mediated Transport
Establishment Of Protein Localization
Internal Peptidyl-lysine Acetylation
Regulation Of Tubulin Deacetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Intracellular Transport
Maintenance Of Protein Location In Cell
Intraciliary Transport Involved In Cilium Morphogenesis
Secretion Of Lysosomal Enzymes
Microtubule-based Transport
Protein Acetylation
Maintenance Of Protein Location
Regulation Of Cell Differentiation
Cytoskeleton-dependent Intracellular Transport
Maintenance Of Location In Cell
Organelle Assembly
Negative Regulation Of Collateral Sprouting
Tagcloud
?
adjustments
associates
confounders
continued
cubic
cv
geriatric
gnri
handgrip
hemodialysis
hospitalization
hospitalizations
malnutrition
mhd
mis
nutritional
observational
outpatients
qol
scales
sf
sf36
spline
sua
tertile
trends
upcoming
uric
y
Tagcloud (Difference)
?
adjustments
associates
confounders
continued
cubic
cv
geriatric
gnri
handgrip
hemodialysis
hospitalization
hospitalizations
malnutrition
mhd
mis
nutritional
observational
outpatients
qol
scales
sf
sf36
spline
sua
tertile
trends
upcoming
uric
y
Tagcloud (Intersection)
?