HGS and CSTF2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		HGS	CSTF2
Gene Name		hepatocyte growth factor-regulated tyrosine kinase substrate	cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Cleavage Body
	Molecular Function	Protein Binding Protein Domain Specific Binding Metal Ion Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Eye color traits ( 20463881)
Protein-Protein Interactions		138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302	23 interactors: APP BAG6 C14orf1 CHD3 CSTF3 DDX1 ECH1 EEF1G FEZ1 HGS IKBKAP IMMT KAT5 KIAA1377 POLR2A SPAG8 SS18L1 SUB1 SYMPK TFG UBQLN1 UBQLN4 ZNF341
Entrez ID		9146	1478
HPRD ID		05085	02652
Ensembl ID		ENSG00000185359	ENSG00000101811
Uniprot IDs		O14964	E7EWR4 P33240
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	1P1T 2J8P
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance	MRNA Polyadenylation Gene Expression RNA Polyadenylation RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process MRNA Processing MRNA 3'-end Processing Regulation Of Protein Metabolic Process MRNA Metabolic Process RNA 3'-end Processing Regulation Of Gene Expression Regulation Of Metabolic Process RNA Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transcription Elongation From RNA Polymerase II Promoter Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Nitrogen Compound Metabolic Process Regulation Of Dendrite Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Regulation Of ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury DNA-templated Transcription, Elongation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Splicing Regulation Of Dendrite Development Collateral Sprouting Axon Midline Choice Point Recognition
Tagcloud ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?